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Stroke:脑小血管病患者最后是否会发展为痴呆?

2020-03-01 shaosai MedSci原创

脑小血管病(SVD)是血管性认知损害最常见的原因,其中很大比例的患者最后演变为痴呆。本研究旨在评价扩散张量成像图像分割技术(DSEG)预测认知下降程度及演变为痴呆的价值,从而提供一种有种的预后手段。

背景与目的
脑小血管病(SVD)是血管性认知损害最常见的原因,其中很大比例的患者最后演变为痴呆。本研究旨在评价扩散张量成像图像分割技术(DSEG)预测认知下降程度及演变为痴呆的价值,从而提供一种有种的预后手段。
方法
本研究共纳入了9例SVD患者,每年进行磁共振检查(连续3年)和认知功能评价(连续5年)。利用DSEG-θ作为全脑SVD严重程度的指标。参考DSMMDV标准来诊断痴呆。利用Cox回归分析评价DSEG指标、血管危险指标与痴呆高风险的相关性。利用线性判别分析对病情稳定组与脑痴呆患者进行分类。
结果
DSEG- θ与高级功能和整体认知功能具有相关性(P<0.001)。其中有18例(18.2%)患者演变为痴呆。基线DSEG-θ 预测痴呆的分类率为75.95%,其曲线下面积为0.839。最佳分类模型包括基线DSEG-θ 、DSEG-θ 变化、年龄、性别和发病前的智商(平衡分类率为79.65%,曲线下面积为0.903)。
结论
本研究表面DSEG是一种能够利用单一影像学检查方法准确评估SVD患者脑微结构损害的全自动分析技术。DSEG-θ 是识别SVD患者演变为痴呆高风险的重要工具,具有评估SVD严重程度的潜能。
原始出处:
Williams OA, Zeestraten EA, Benjamin P, et al,Predicting Dementia in Cerebral Small Vessel Disease Using an Automatic Diffusion Tensor Image Segmentation Technique.Stroke. 2019.DOI: 10.1161/STROKEAHA.119.025843
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    2020-03-01 junJUN

    老年人痴呆何药可用??

    0

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