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Antimicrob Agents Chemother:长途跋涉也能导致耐药细菌的传播

2015-08-23 MedSci MedSci原创

在印度和中非短途学习的的瑞典交换生返回国内后,发现机体肠道微生物的耐药基因多样性增加,研究人员将文章发表在 Antimicrobial Agents and Chemotherapy。在这项研究中,研究人员发现:交换生体内的磺胺类耐药基因增加2.6倍,甲氧苄啶耐药基因增加7.7倍,β-内酰胺类耐药基因增加2.6倍。且这35名交换生之前并未有任何抗生素使用史和耐药史。在他们作为交换生学习之前他们体内

在印度和中非短途学习的的瑞典交换生返回国内后,发现机体肠道微生物的耐药基因多样性增加,研究人员将文章发表在 Antimicrobial Agents and Chemotherapy。


在这项研究中,研究人员发现:交换生体内的磺胺类耐药基因增加2.6倍,甲氧苄啶耐药基因增加7.7倍,β-内酰胺类耐药基因增加2.6倍。且这35名交换生之前并未有任何抗生素使用史和耐药史。在他们作为交换生学习之前他们体内的耐药基因也不明显,但是在他们学毕归来之时体内肠道耐药基因却如此明显。

这引发了大家对抗生素耐药性的强烈关注。瑞典优密欧大学传染控制科的Anders Johansson博士说道:“我是一名感染科医生,抗生素的使用使我可以治愈十年前无法治愈的患者,它具有十分强大的作用。”

但是Johansson博士对此十分怀疑,因为抗生素的滥用会产生耐药性,甚至导致超级细菌的产生。这是个十分严峻的问题。 患者入院时有可能会携带耐药细菌作为自身肠道菌群的一部分,即使使用抗生素,但是耐药细菌数目非常多,且耐药性十分强大,使得耐药细菌无法清除,且患者的治疗过程十分困难。

事实上,交换生在旅行之前或在旅行期间都从未使用抗生素,但体内的耐药基因的确增加。研究人员认为,可能是饮用水被污染,或食物中还有耐药细菌等,导致交换生体内耐药基因增加。

Johansson博士说:“收集耐药基因的样本很简单。我们要求去海外交流的学生在出国前后都留取大便标本。但是与以往研究不同的是,我们如今使用宏观基因组测序的方法。因此我们可以探究每一个学生大便标本的所有微生物群,并发现所有的耐药基因。”博士认为,为了减少民众对抗生素的耐药性,首先要进行完善医疗系统和健全相应体制。为了避免耐药细菌的扩散,旅游或其他各种原因出国的民众在相应活动结束后应立即回到自己的国家。

原始出处:

Bengtsson-Palme J, Angelin M, Huss M, Kjellqvist S, Kristiansson E, Palmgren H, Larsson DG, Johansson A.The human gut microbiome as a transporter of antibiotic resistance genes between continents.Antimicrob Agents Chemother. 2015 Aug 10.


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    2016-03-28 xjy02
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    2016-04-30 grace5700
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    2015-12-13 仁医06
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