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Neurology:根据脑白质高信号模式可判断脑出血病因?

2016-03-23 phylis 译 MedSci原创

目的:为了区分两种出血倾向的小血管疾病(SVD):淀粉样脑血管病(CAA)和高血压性动脉病(HA)的白质高信号(WHM)的不同。方法:分析单中心前瞻性研究中,SVD相关的脑内出血(ICH)的患者。对比CAA和HA组四个预定义的皮层下白质高信号模式。白质高信号模式为:1. 皮质下多发斑点状,2. 围基底节区(BG)3.后皮层下大片斑片状,4.前皮层下斑片状白质高信号。应用多变量逻辑回归确定其他影像(

目的:为了区分两种出血倾向的小血管疾病(SVD):淀粉样脑血管病(CAA)和高血压性动脉病(HA)的白质高信号(WHM)的不同。

b分析单中心前瞻性研究中,SVD相关的脑内出血(ICH)的患者。对比CAA和HA组四个预定义的皮层下白质高信号模式。白质高信号模式为:1. 皮质下多发斑点状,2. 围基底节区(BG)3.后皮层下大片斑片状,4.前皮层下斑片状白质高信号。应用多变量逻辑回归确定其他影像(脑内微出血[CMBs],扩大的血管周围间隙[EPVS])和SVD临床指标的相关性。     

结果:队列研究包括319个CAA患者和137个HA患者。与HA组相比,CAA组患者皮质下多发斑点状模式出现较多(29.8% vs 16.8%; p = 0.004)。围基底节区白质高信号更多见于HA(19% vs 7.8%; p = 0.001)。在多变量逻辑回归分析中,皮质下多发斑点状与脑微出血(OR:1.23; 95% CI: 1.01-1.50, p = 0.039) 和半卵圆中心高度扩大的血管周围间隙(OR 2.43; 95% CI 1.56-3.80, p < 0.0001)相关。年龄(OR 1.05; 95% CI 1.02-1.09, p = 0.002),深部微出血(OR 2.46; 95% CI 1.44-4.20, p = 0.001),WMH总体积量(OR 1.02; 95% CI 1.01-1.04, p = 0.002)及高度BG EPVS(OR 8.81; 95% CI 3.37-23.02, p < 0.0001) 是围基底节区白质高信号的预测因子。

结论:MRI上可见的皮质下脑白质疏松的不同类型可能有助于潜在微出血的类型和ICH患者组织损伤的机制的探讨。

原文出处:

Charidimou A,Boulouis G,et al. White matter hyperintensity patterns in cerebral amyloid angiopathy and hypertensive arteriopathy. Neurology. 2016 Jan 8.

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    2016-10-06 yinhl1978
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    2016-03-28 Lisa971

    预测性!

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1950794, encodeId=ec441950e94e6, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Sun Jan 08 22:42:00 CST 2017, time=2017-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765570, encodeId=f79b1e65570e9, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Jan 31 18:42:00 CST 2017, time=2017-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999665, encodeId=2fa019996650a, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Oct 06 18:42:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74046, encodeId=82bce40465e, content=预测性!, beContent=null, objectType=article, channel=null, level=null, likeNumber=242, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Mon Mar 28 08:07:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417558, encodeId=a4df141e55869, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Fri Mar 25 09:42:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506825, encodeId=f157150682548, content=<a href='/topic/show?id=a1af849e063' target=_blank style='color:#2F92EE;'>#脑白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84970, encryptionId=a1af849e063, topicName=脑白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79949824561, createdName=rgjl, createdTime=Fri Mar 25 09:42:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
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