ASCO GI 2015：化疗+ramucirumab二线治疗进展期结直肠癌疗效可观

2015-01-21 黄蕾蕾中国医学论坛报

一项针对1072例结直肠癌">进展期结直肠癌的Ⅲ期研究发现，靶向药物ramucirumab与FOLFIRI化疗联合较FOLFIRI标准治疗有一定的生存优势。平均来看，FOLFIRI+ramucirumab联合治疗的患者生存期较FOLFIRI+安慰剂治疗者延长了6个月。这一结果为进展期结直肠癌二线治疗新策略的发展提供了概念验证(proof-of-concept)，特别是对一线化疗联合贝伐珠单抗

一项针对1072例结直肠癌">进展期结直肠癌的Ⅲ期研究发现，靶向药物ramucirumab与FOLFIRI化疗联合较FOLFIRI标准治疗有一定的生存优势。平均来看，FOLFIRI+ramucirumab联合治疗的患者生存期较FOLFIRI+安慰剂治疗者延长了6个月。这一结果为进展期结直肠癌二线治疗新策略的发展提供了概念验证(proof-of-concept)，特别是对一线化疗联合贝伐珠单抗治疗后出现疾病进展者，可采用标准化疗联合抗血管生成药物治疗。

主要研究作者、瓦尔德希伯伦肿瘤研究所主任Josep Tabernero教授：进展期结直肠癌可谓是“绝症”，特别是初治无效后很难治愈。我们的研究纳入了一些肿瘤生长快速的患者，因此研究结果与我们在临床实践中遇到的典型患者存在相关性。令人鼓舞的是，如今我们在二线治疗中有了另一些安全选择，可在标准化疗基础上增加获益。

ASCO观点

ASCO专家Smitha S. Krishnamurthi教授：Ramucirumab作为一种血管生成抑制剂，已经证明了其在抗胃癌、肺癌方面的活性，现在发现针对结直肠癌同样有效，这真是一个好消息。如今，对于出现进展的结直肠癌患者，二线治疗可以选择FOLFIRI化疗与贝伐珠单抗或阿柏西普联合，也许还可能是FOLFIRI化疗与ramucirumab联合。进一步研究需要明确ramucirumab在一线治疗或其他情况下抗结直肠癌的活性。

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2015-10-27 licz0423

#进展期#

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2015-07-14 quxin068

#ASC#

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2015-03-23 snf701207

#mAb#

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2015-03-22 zywlvao

#进展期结直肠癌#

57 0
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2015-01-23 crystal0564

#结直肠#

76 0
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2015-01-23 liuli5081

#Ramucirumab#

55 0
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2015-01-23 ms5768352621950538

#二线治疗#

56 0

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