致死率高达50%的超级病菌KPC现身澳大利亚，超过MERS

2015-06-20 MedSci 澳洲网

根据澳洲网17日报道，一种致死率高达50%的超级病菌已经在澳大利亚维多利亚州感染数十人。据悉，从去年开始，这种超级病菌已经在维州一家医院直接致2人死亡。维州各医院升级防控措施据报道，维多利亚州各大医院从即日起开始高度关注这种名为耐碳青霉烯类抗生素肺炎克雷伯菌（Klebsiella pneumoniae carbapenemase，KPC）的超级病菌。因为该超级病菌的一个新变

根据澳洲网17日报道，一种致死率高达50%的超级病菌已经在澳大利亚维多利亚州感染数十人。据悉，从去年开始，这种超级病菌已经在维州一家医院直接致2人死亡。

维州各医院升级防控措施

据报道，维多利亚州各大医院从即日起开始高度关注这种名为耐碳青霉烯类抗生素肺炎克雷伯菌（Klebsiella pneumoniae carbapenemase，KPC）的超级病菌。因为该超级病菌的一个新变种已经在过去3年间使57名维州人患病，而且该病菌正在该州圣文森特(St Vincent)医院的患者间传播。

维州卫生厅发言人称，维州感染该病菌的57人中已经有18人死亡，但目前尚不清楚是否是该病菌直接导致他们死亡。据悉，该病菌可以在患者的肠道内繁殖却不会让他们出现任何病症。

但圣文森特医院传染科专家韦斯万坦(Kumar Visvanathan)称，这种超级病菌去年直接导致该医院2名患者死亡。他称，从2012年开始，圣文森特医院已经确诊28名患者。其中，有10人因为感染病菌而住院。

据悉，圣文森特医院已经加强病菌感染防控程序，对易感患者进行筛查，加速检测程序，对病房进行蒸汽消毒，并教育患者做好手部清洁，对带菌者立即进行隔离等。

据了解，维州今年共发现5起病例。韦斯万坦称：“我们将竭尽所能来歼灭KPC超级病菌，我们在现阶段取得了一些胜利。我认为，我们能控制住局面。”

维州首位患者在海外感染

据悉，维州第一例KPC感染患者很有可能是从海外感染病菌然后带回维州的。维州卫生厅已经下令对去年有过海外旅行经历的新入院患者加强控制手段。维州卫生厅发言人称，已经在维州其他医院也发现类似病例，但目前尚不能透露这些医院的名称。

据了解，KPC超级病菌会在患者的肠道内繁殖，但不会引发临床疾病。但有些患者会发展成为更为难治疗的尿路感染及血液感染。这要依靠患者自身的免疫力强弱来抵抗病菌，以及患者对抗生素治疗的反应。

韦斯万坦称，KPC超级病菌近年在海外很流行，主要在希腊、意大利及亚洲部分国家流行。患者主要在医院内感染此种病菌，途径是通过人类排泄物，病菌会传播到其他物体表面。

维州卫生厅长亨里斯(Jill Hennessy)称，维州不会爆发大规模公共卫生事件。但维州正在加强防控并会及时报道事件。

小知识：克雷伯菌碳青霉烯酶（KlebsiellaPneumoniaecarbapenemase，KPC）

1996年美国北卡罗纳首先报道了肺炎克雷伯菌中发现的KPC-1，2年后在美国马里兰的肺炎克雷伯菌中发现KPC-2。自2000年以后，KPC家族在美国的新英格兰和亚特兰大地区陆续被发现，主要在克雷伯菌属中，也在其他菌株中被发现，到目前为止，共发现了4种亚型，包括KPC-1～4，由质粒介导，能被克拉维酸抑制。2007年LeavittA等[1]在从以色列医院中分离到产KPC-2和KPC-3的肺炎克雷伯菌；同年哥伦比亚VillequsMV等首次报道在铜绿假单胞菌中检测出KPC-2酶，这说明KPC很可能从肠杆菌向非发酵菌传播；汤瑾等对在瑞金医院发现1株对亚胺培南耐药的肺炎克雷伯菌A1500进行研究，发现该菌株能产KPC-2酶，结合试验和Southernblot结果显示产KPC-2酶的耐药基因位于1个50kb大小的可转移的质粒上，且与国外报道的携带产KPC-2酶质粒大小相同。由于携带KPC酶的质粒具有可转移性，其具有造成大规模医院感染的分子生物学特性，同时对碳青霉烯类抗菌药物的耐药使其对该类酶的研究越来越重要

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2015-09-12 axin009

#致死率#

57 0
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2015-07-14 2863454482

沉默的杀手

138 0
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2016-05-02 仁心济世

#ERS#

62 0
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2015-06-26 fatalmelanie

病毒感染没有特效药

138 0
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2015-06-26 stupidox

克拉维酸可以抑制啊

149 0
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2015-06-25 huaxipanxing

可怕

153 0
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2015-06-25 nizongzan

病毒好可怕

134 0
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2015-06-23 惜言

可怕啊

157 0
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2015-06-22 caierhong

积极预防

105 0
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2015-06-22 huangwukui

我觉得没有MERS可怕

99 0

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致死率高达50%的超级病菌KPC现身澳大利亚，超过MERS

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致死率高达50%的超级病菌KPC现身澳大利亚，超过MERS

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