Baidu
map

PLoS Genet:吸烟会加快面部老化,你还敢吸烟吗?

2019-11-07 佚名 细胞

“吸烟脸”指的是吸烟者看起来比他们实际年龄大的一种状况。这是大量吸烟所造成的许多负面影响之一。最近,来自布里斯托大学的Louise Millard及其同事在发表于《 PLOS Genetics》杂志上的一项新研究中报告了这些发现。

“吸烟脸”指的是吸烟者看起来比他们实际年龄大的一种状况。这是大量吸烟所造成的许多负面影响之一。最近,来自布里斯托大学的Louise Millard及其同事在发表于《 PLOS Genetics》杂志上的一项新研究中报告了这些发现。

为了确定大量吸烟的带来的影响,科学家们希望将与吸烟有关的遗传变异以及与吸烟无关的遗传变异人为地分开。为了同时识别这两种类型的影响,研究人员使用了两种数据分析方法的组合,进而针对英国相关“生物库”中的数据进行分析。他们将人们分为两组。第一组包括从未吸烟的人,第二个包括目前正在吸烟或曾经有过吸烟史的人。

该分析搜索了18,000个特征,除了新发现的“吸烟者面部衰老更快“之外,还发现了先前报道的几种吸烟带来的影响。确定的吸烟会带来的已知影响包括肺功能恶化,以及患慢性阻塞性肺疾病(COPD)和皮肤癌等。

关于这项研究,作者Louise Millard说:“我们提出了一种新颖的方法,可用于探索影响健康的因果机制,并展示了这种方法在探究吸烟对身体健康的影响方面的能力。我们搜索了成千上万的特征以找出潜在的后果。除了确定一些已知的不利影响(例如对肺部健康),我们还发现了吸烟量增加对加快面部衰老的不利影响。”

原始出处:
Louise A. C. Millard, Marcus R. Munafò, Kate Tilling,et al. MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging. PLOS Genetics, 2019; 15 (10): e1008353 DOI: 10.1371/journal.pgen.1008353

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2049245, encodeId=8b782049245e8, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sun Sep 06 10:14:00 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734183, encodeId=7f221e3418308, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Sep 21 21:14:00 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1686317, encodeId=83c4168631e05, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Mon Jul 06 16:14:00 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388037, encodeId=104c138803eb5, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Nov 09 04:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2020-09-06 cy0324
  2. [GetPortalCommentsPageByObjectIdResponse(id=2049245, encodeId=8b782049245e8, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sun Sep 06 10:14:00 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734183, encodeId=7f221e3418308, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Sep 21 21:14:00 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1686317, encodeId=83c4168631e05, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Mon Jul 06 16:14:00 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388037, encodeId=104c138803eb5, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Nov 09 04:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2020-09-21 canlab
  3. [GetPortalCommentsPageByObjectIdResponse(id=2049245, encodeId=8b782049245e8, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sun Sep 06 10:14:00 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734183, encodeId=7f221e3418308, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Sep 21 21:14:00 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1686317, encodeId=83c4168631e05, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Mon Jul 06 16:14:00 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388037, encodeId=104c138803eb5, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Nov 09 04:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2049245, encodeId=8b782049245e8, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sun Sep 06 10:14:00 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734183, encodeId=7f221e3418308, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Sep 21 21:14:00 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1686317, encodeId=83c4168631e05, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Mon Jul 06 16:14:00 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388037, encodeId=104c138803eb5, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Nov 09 04:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]

相关资讯

J Dent Res:吸烟改变早发牙周炎的遗传风险

牙周炎发病率低,具有一些严重疾病的症状并且早发且进展迅速。诊断依赖于青少年或年轻成人牙槽骨的严重破坏。遗传易感性的变化和吸烟是已知的风险因素,但是它们之间的相互作用对疾病易感性的变化还未可知。这篇研究的目的是为了评估早发性牙周炎的遗传风险变化,并揭示它们对烟草摄入的影响。

Lancet Gastroen Hepatol:全球胰腺癌疾病负担研究——1990-2017

研究发现,从1990年到2017年,在全球范围内,胰腺癌导致的死亡、病例和DALYs的数量增加了一倍以上。随着人口老龄化,胰腺癌的发病率可能会继续上升。预防战略应侧重于可改变的风险因素防控

EASD中国之声:丈夫爱吸烟,妻子患糖尿病风险陡然增加

吸烟已被确定为糖尿病的危险因素,主动吸烟与糖尿病的关系已经有很多证据。然而,被动吸烟与血糖/糖尿病之间的关系仍不清楚。本届EASD大会上一项来自中国的横断面研究引起与会者的关注。

BMJ:慢性阻塞性肺病患者预后预测模型

本研究对COPD患者预后模型进行了详细评估。调查结果表明,大部分在发展过程中存在若干方法上的缺陷,外部验证率较低

Lancet Respir Med:少量吸烟同样有害!研究称:每天5支肺损伤长达数十年

许多人认为每天抽几支烟并没有那么糟糕,但事实并非如此。

全面利弊解析!生活方式如何影响心脏健康|GW-ICC2019

关于生活方式与心血管健康,看看GW-ICC2019大会上有哪些最新内容~

Baidu
map
Baidu
map
Baidu
map