Diabetic Med：疼痛糖尿病周围神经病变中维生素D水平降低

2019-03-26 不详网络

<span style="font-size:9.0pt;font-family:宋体;mso-ascii-theme-font:major-fareast; mso-fareast-theme-font:major-fareast;mso-hansi-theme-font:major-fareast; color:black;mso-bidi-font-weight:bold">近日，国际杂

近日，国际杂志《Diabetic Med》上在线发表一项关于疼痛糖尿病周围神经病变中维生素D水平降低的研究。

最近的研究报道了低维生素D水平与糖尿病周围神经病变之间的关联。然而，其中许多并未区分患有疼痛性糖尿病周围神经病的人和患有无痛性糖尿病周围神经病的人，或评估主要的混杂因素，包括日光暴露和日常活动。研究人员的研究解决了这些局限性，并详细评估了表型糖尿病周围神经病变和对照组患者的维生素D水平。

45名患有2型糖尿病的白人欧洲人和14名健康志愿者接受了临床和神经生理学评估。然后将患有2型糖尿病的人分成三组（17名患有疼痛性糖尿病周围神经病，14名患有无痛性糖尿病周围神经病，14名患有无糖尿病周围神经病）。所有人都进行了季节性日光照射和日常活动的测量，进行了下肢皮肤活检，并在7月至9月的夏季测量了25-羟基维生素D.

研究发现，校正年龄，BMI，活动评分和阳光照射后，糖尿病周围神经病变患者的25-羟基维生素D水平（nmol/ l）（se）显著降低[疼痛性糖尿病周围神经病变34.9（5.8），健康志愿者62.05（ 6.7），无糖尿病周围神经病变49.6（6.1），无痛性糖尿病周围神经病变53.1（6.2）；ANCOVA P = 0.03]。直接逻辑回归用于评估七个独立变量对疼痛性糖尿病周围神经病变的影响。维生素D是唯一能够对模型做出统计学显著贡献的独立变量，倒数比值比为1.11。25-羟基维生素D水平较低也与冷检测阈值较低（r = 0.39，P = 0.02）和表皮下神经纤维密度（r=0.42，P=0.01）相关。

研究人员已经证实了具有疼痛的糖尿病周围神经病变的充分表征的人中25-羟基维生素D水平的显著差异，同时考虑了主要的混杂因素。这表明维生素D可能在疼痛性糖尿病周围神经病变的发病机制中发挥作用。需要进一步的前瞻性和干预性试验来证明低维生素D水平与疼痛性糖尿病周围神经病变之间的因果关系。

原始出处：

P. Shillo， D. Selvarajah，M. Greig，et al. Reduced vitamin D levels in painful diabetic peripheral neuropathy

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2019-11-09 ms5439512287675881

#BET#

51 0
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2019-06-14 chenzhuanggui

#Diabetic#

82 0
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2019-12-23 grace5700

#糖尿病周围神经病变#

152 0
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2019-10-20 ms9608593228839890

#DIA#

67 0
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2019-06-07 Smile2692

#周围神经#

59 0
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2019-03-28 axin012

#神经病#

64 0
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2019-03-28 lingaifan

#神经病变#

46 0
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2019-03-28 ms3994565386320060

#Med#

0 0
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2019-03-26 misszhang

谢谢MedSci提供最新的资讯

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Diabetic Med：疼痛糖尿病周围神经病变中维生素D水平降低

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