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Dig Dis Sci:粪便钙卫蛋白可以预测炎症性肠病患者的不良妊娠结局

2021-05-05 MedSci原创 MedSci原创

粪钙卫蛋白(FCP)是炎症反应时胃肠道中中性粒细胞和巨噬细胞分泌的蛋白质,它是用于区分肠易激综合征和炎症性肠病(IBD)的最敏感的非侵入性的指标。

      粪钙卫蛋白(FCP)是炎症反应时胃肠道中中性粒细胞和巨噬细胞分泌的蛋白质,它是用于区分肠易激综合征和炎症性肠病(IBD)的最敏感的非侵入性的指标。此外,在患有IBD的患者中,FCP是监测疾病活动,预测疾病复发的有用指标。但是,粪钙卫蛋白在预测炎症性肠病(IBD)中妊娠相关结局中的作用尚不清楚。因此,本项研究旨在确定在怀孕期间粪便钙卫蛋白的增加是否与IBD的不良妊娠结局有关。

 

      本项研究是一项针对IBD妇女的多中心队列研究,这些妇女在怀孕期间接受了粪便钙卫蛋白的监测。粪便钙卫蛋白水平按妊娠时间进行分层,并记录与妊娠相关的不良后果。Mann–Whitney U检验评估了连续变量之间的差异,而分类变量使用卡方检验进行了比较。

 

      本项研究共纳入了八十五名患有IBD的妇女。研究结果显示进行紧急剖宫产的患者的早孕期粪便钙卫蛋白高于阴道分娩的患者(503 ug / g,IQR 1554.3 ug / g vs. 130 ug / g,IQR 482 ug / g,p = .030)。非自发分娩者(334.5 ug / g,IQR 1411.0 ug / g)的中期妊娠粪钙卫蛋白高于自发分娩者(116.5 ug / g,IQR 227.1 ug / g)(p = .025)。妊娠中期粪便钙卫蛋白≥250 ug / g的婴儿的早产发生率升高(35.3%VS 3.8%)(p = .049),

图:粪钙卫蛋白与妊娠妇女不良结局的危险因素

       研究最后作者说道:粪钙卫蛋白可能是预测IBD患者妊娠相关不良结局最有效的非侵入性标志物。

 

 

原始出处:

Parul Tandon. Et al. Fecal Calprotectin May Predict Adverse Pregnancy-Related Outcomes in Patients with Inflammatory Bowel Disease. Digestive Diseases and Sciences.2021.

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    2021-09-15 爆笑小医
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    2021-05-11 1471fa2dm76暂无昵称

    不错不错

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  4. 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target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96334, encryptionId=dd05963343f, topicName=钙卫蛋白), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed May 05 21:07:07 CST 2021, time=2021-05-05, status=1, ipAttribution=)]
    2021-05-07 Homburg
  5. 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  6. 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  7. 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topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600093, encodeId=01e91600093f2, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963341, encodeId=327496334145, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Fri May 07 10:44:34 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963241, encodeId=387096324123, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201029/dccc73f30f6b4172a975444800235105/1bbf3e63a27c425aadf73e7dcda9f617.jpg, createdBy=0da92443903, createdName=翩翩白衣少年, createdTime=Thu May 06 22:30:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962900, encodeId=315896290054, content=<a href='/topic/show?id=dd05963343f' target=_blank style='color:#2F92EE;'>#钙卫蛋白#</a>是一个好东西!!可以预测<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96334, encryptionId=dd05963343f, topicName=钙卫蛋白), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed May 05 21:07:07 CST 2021, time=2021-05-05, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2013622, encodeId=5dd32013622b8, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Sep 15 07:22:15 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964743, encodeId=b503964e436f, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=09795193208, createdName=1471fa2dm76暂无昵称, createdTime=Tue May 11 22:27:15 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392979, encodeId=0de313929e927, content=<a href='/topic/show?id=8c9f4492370' target=_blank style='color:#2F92EE;'>#妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44923, encryptionId=8c9f4492370, topicName=妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466966, encodeId=446014669664b, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469463, encodeId=6195146946325, content=<a href='/topic/show?id=850120501c5' target=_blank style='color:#2F92EE;'>#不良妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20501, encryptionId=850120501c5, topicName=不良妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa987034131, createdName=cmsvly, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547436, encodeId=b03c154e436e3, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600093, encodeId=01e91600093f2, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963341, encodeId=327496334145, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Fri May 07 10:44:34 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963241, encodeId=387096324123, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201029/dccc73f30f6b4172a975444800235105/1bbf3e63a27c425aadf73e7dcda9f617.jpg, createdBy=0da92443903, createdName=翩翩白衣少年, createdTime=Thu May 06 22:30:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962900, encodeId=315896290054, content=<a href='/topic/show?id=dd05963343f' target=_blank style='color:#2F92EE;'>#钙卫蛋白#</a>是一个好东西!!可以预测<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96334, encryptionId=dd05963343f, topicName=钙卫蛋白), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed May 05 21:07:07 CST 2021, time=2021-05-05, status=1, ipAttribution=)]
    2021-05-07 smart Ren

    学习学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2013622, encodeId=5dd32013622b8, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Sep 15 07:22:15 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964743, encodeId=b503964e436f, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=09795193208, createdName=1471fa2dm76暂无昵称, createdTime=Tue May 11 22:27:15 CST 2021, time=2021-05-11, status=1, ipAttribution=), 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createdBy=03cc6863823, createdName=Homburg, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469463, encodeId=6195146946325, content=<a href='/topic/show?id=850120501c5' target=_blank style='color:#2F92EE;'>#不良妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20501, encryptionId=850120501c5, topicName=不良妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa987034131, createdName=cmsvly, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547436, encodeId=b03c154e436e3, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600093, encodeId=01e91600093f2, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963341, encodeId=327496334145, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Fri May 07 10:44:34 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963241, encodeId=387096324123, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201029/dccc73f30f6b4172a975444800235105/1bbf3e63a27c425aadf73e7dcda9f617.jpg, createdBy=0da92443903, createdName=翩翩白衣少年, createdTime=Thu May 06 22:30:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962900, encodeId=315896290054, content=<a href='/topic/show?id=dd05963343f' target=_blank style='color:#2F92EE;'>#钙卫蛋白#</a>是一个好东西!!可以预测<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96334, encryptionId=dd05963343f, topicName=钙卫蛋白), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed May 05 21:07:07 CST 2021, time=2021-05-05, status=1, ipAttribution=)]
    2021-05-06 翩翩白衣少年

    学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2013622, encodeId=5dd32013622b8, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Sep 15 07:22:15 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964743, encodeId=b503964e436f, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=09795193208, createdName=1471fa2dm76暂无昵称, createdTime=Tue May 11 22:27:15 CST 2021, time=2021-05-11, status=1, ipAttribution=), 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createdBy=03cc6863823, createdName=Homburg, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469463, encodeId=6195146946325, content=<a href='/topic/show?id=850120501c5' target=_blank style='color:#2F92EE;'>#不良妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20501, encryptionId=850120501c5, topicName=不良妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa987034131, createdName=cmsvly, createdTime=Fri May 07 11:22:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547436, encodeId=b03c154e436e3, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Fri May 07 10:44:34 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963241, encodeId=387096324123, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201029/dccc73f30f6b4172a975444800235105/1bbf3e63a27c425aadf73e7dcda9f617.jpg, createdBy=0da92443903, createdName=翩翩白衣少年, createdTime=Thu May 06 22:30:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962900, encodeId=315896290054, content=<a href='/topic/show?id=dd05963343f' target=_blank style='color:#2F92EE;'>#钙卫蛋白#</a>是一个好东西!!可以预测<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96334, encryptionId=dd05963343f, topicName=钙卫蛋白), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed May 05 21:07:07 CST 2021, time=2021-05-05, status=1, ipAttribution=)]
    2021-05-05 小小医者

    #钙卫蛋白#是一个好东西!!可以预测#炎症性肠病#

    0

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