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EHJ:LDL-C/HDL-C比例是男性患者心血管事件的有效预测因素

2013-09-04 刘揆亮 译 医学论坛网

近日,在2013年欧洲心脏病学会年会上,来自日本高松KKR高松医院的 I. Matsumoto的学者发表研究结果,研究发现,LDL-C/HDL-C比例是男性患者心血管事件的一项有价值的预测因素。次外,PCI后的二级预防需要维持LDL-C/HDL-C比例低于1.5,相关论文发表在在欧洲心脏病学杂志(European Heart Journal)(2013)34(摘要补充)

近日,在2013年欧洲心脏病学会年会上,来自日本高松KKR高松医院的 I. Matsumoto的学者发表研究结果,研究发现,LDL-C/HDL-C比例是男性患者心血管事件的一项有价值的预测因素。次外,PCI后的二级预防需要维持LDL-C/HDL-C比例低于1.5,相关论文发表在在欧洲心脏病学杂志(European Heart Journal)(2013)34(摘要补充),136。 

一些临床研究证实低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-C/HDL-C)是心血管疾病的一项良好预测因素。本研究的目的是明确LDL-C/HDL-C比例是否可能影响经皮冠状动脉干预(PCI)后的转归。

877名成功进行PCI的男性患者分为以下三组:LDL-C/HDL-C≤1.5组(178)名,LDL-C/HDL-C= 1.5-2.0组(261名),LDL-C/HDL-C >2.0(438名)。在这些组中评价了PCI后5年内心血管重大不良事件(MACE)的发生率。MACE定义为心源性死亡、非致死性心肌梗死、新发狭窄和再狭窄。

Kaplan-Meier分析证实LDL-C/HDL-C≤1.5的患者与LDL-C/HDL-C>2.0及LDL-C/HDL-C 在1.5-2之间的患者相比MACE发生率明显更低(P<0.001)。另外,Cox比例风险模型表明LDL-C/HDL-C比例是MACE的独立危险因素。

   ESC 

MACE的累积发生率     

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    2013-09-06 ZGMFX24A
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    2013-09-06 zhwj
  6. [GetPortalCommentsPageByObjectIdResponse(id=2054091, encodeId=bef920540910a, content=<a href='/topic/show?id=c699e024409' target=_blank style='color:#2F92EE;'>#男性患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70244, encryptionId=c699e024409, topicName=男性患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sat Mar 15 12:15:00 CST 2014, time=2014-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643321, encodeId=ecaf1643321a1, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Mon Dec 16 19:15:00 CST 2013, time=2013-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264192, encodeId=64d612641926a, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Sep 06 06:15:00 CST 2013, time=2013-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316400, encodeId=9a89131640054, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Fri Sep 06 06:15:00 CST 2013, time=2013-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422507, encodeId=3066142250eb4, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Fri Sep 06 06:15:00 CST 2013, time=2013-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480808, encodeId=9b141480808f3, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Fri Sep 06 06:15:00 CST 2013, time=2013-09-06, status=1, ipAttribution=)]
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