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Stroke：低血钙和镁水平与颅内动脉瘤破裂！

2018-05-30 xing.T MedSci原创

低血钙镁水平颅内动脉瘤破裂
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由此可见，在这项大型病例对照研究中，诊断时低钙血症和低镁血症与动脉瘤破裂显著相关。低钙血症和低镁血症导致的止血功能受损可能解释这种关联。

低血清钙和镁水平与颅内出血患者的出血程度有关，提示低血钙和低镁血症诱导的凝血功能障碍可能是潜在的机制。近日，卒中领域权威杂志Stroke上发表了一篇研究文章，研究人员假设血清白蛋白校正的总钙和镁水平与颅内动脉瘤破裂有关。

研究人员对1990年至2016年期间在布莱根妇女医院和麻省总医院确诊的4701例患者（包括1201例前瞻性患者）的病历进行了回顾和分析。1275名患者在诊断后一天内的血清钙、镁和白蛋白数值可用。受试者被分成动脉瘤破裂患者和未破裂动脉瘤的对照者。研究人员进行单变量和多变量logistic回归分析以确定血清白蛋白校正的总钙和镁水平与动脉瘤破裂之间的关联。

在多变量分析中，白蛋白校正后的钙（比值比为0.33; 95％可信区间为0.27-0.40）和镁（比值比为0.40; 95％可信区间为0.28-0.55）离子与颅内动脉瘤破裂呈显著负相关。

由此可见，在这项大型病例对照研究中，诊断时低钙血症和低镁血症与动脉瘤破裂显著相关。低钙血症和低镁血症导致的止血功能受损可能解释这种关联。

原始出处：

Anil Can, et al. Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms.Stroke. 2018.https://doi.org/10.1161/STROKEAHA.118.020963

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    2018-07-24 qblt

    #颅内动脉瘤破裂#

    0

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    2018-06-01 易水河

    学习学习吧

    0

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    2018-06-01 andy2091

    #血钙#

    0

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    2018-05-30 baihao215

    宝贵的数据.不断产生资料

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2053332, encodeId=150520533322e, content=<a href='/topic/show?id=a4c91003847b' target=_blank style='color:#2F92EE;'>#颅内动脉瘤破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100384, encryptionId=a4c91003847b, topicName=颅内动脉瘤破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Tue Jul 24 08:55:00 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320494, encodeId=926c32049446, content=学习学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Jun 01 07:33:45 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532535, encodeId=b0251532535e9, content=<a href='/topic/show?id=2216899e2dd' target=_blank style='color:#2F92EE;'>#血钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89972, encryptionId=2216899e2dd, topicName=血钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=582f12352979, createdName=andy2091, createdTime=Fri Jun 01 01:55:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320065, encodeId=66d6320065a9, content=宝贵的数据.不断产生资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Wed May 30 22:50:24 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319996, encodeId=4b7a319996b7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 30 13:24:21 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319971, encodeId=15913199e11e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 30 12:48:38 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319957, encodeId=19c131995efd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Wed May 30 12:27:50 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
    2018-05-30 明月清辉

    谢谢分享.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2053332, encodeId=150520533322e, content=<a href='/topic/show?id=a4c91003847b' target=_blank style='color:#2F92EE;'>#颅内动脉瘤破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100384, encryptionId=a4c91003847b, topicName=颅内动脉瘤破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Tue Jul 24 08:55:00 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320494, encodeId=926c32049446, content=学习学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Jun 01 07:33:45 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532535, encodeId=b0251532535e9, content=<a href='/topic/show?id=2216899e2dd' target=_blank style='color:#2F92EE;'>#血钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89972, encryptionId=2216899e2dd, topicName=血钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=582f12352979, createdName=andy2091, createdTime=Fri Jun 01 01:55:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320065, encodeId=66d6320065a9, content=宝贵的数据.不断产生资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Wed May 30 22:50:24 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319996, encodeId=4b7a319996b7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 30 13:24:21 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319971, encodeId=15913199e11e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 30 12:48:38 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319957, encodeId=19c131995efd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Wed May 30 12:27:50 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
    2018-05-30 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2053332, encodeId=150520533322e, content=<a href='/topic/show?id=a4c91003847b' target=_blank style='color:#2F92EE;'>#颅内动脉瘤破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100384, encryptionId=a4c91003847b, topicName=颅内动脉瘤破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Tue Jul 24 08:55:00 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320494, encodeId=926c32049446, content=学习学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Jun 01 07:33:45 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532535, encodeId=b0251532535e9, content=<a href='/topic/show?id=2216899e2dd' target=_blank style='color:#2F92EE;'>#血钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89972, encryptionId=2216899e2dd, topicName=血钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=582f12352979, createdName=andy2091, createdTime=Fri Jun 01 01:55:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320065, encodeId=66d6320065a9, content=宝贵的数据.不断产生资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Wed May 30 22:50:24 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319996, encodeId=4b7a319996b7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 30 13:24:21 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319971, encodeId=15913199e11e, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 30 12:48:38 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319957, encodeId=19c131995efd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Wed May 30 12:27:50 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
    2018-05-30 1201e5c5m39暂无昵称

    学习了

    0

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