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JAHA:心脏肥大与大脑衰老相关

2021-09-01 网络 网络

LV直径和质量与较低的整体和区域性CT以及一般人群中较大的WMH负担相关。这些结果突出了LV肥大与认知能力下降和痴呆之间相关性的大脑结构基础。

最近,有研究报道左心室(LV)肥大与老年人脑结构的不良变化相关,尤其是白质高信号(WMH)的负担增加。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,尚不清楚更大的LV大小或质量是否也与中年人的WMH负担相关。此外,迄今为止尚未研究分析其与脑皮质厚度(CT)变化之间的关系。


该研究纳入了1602名LV射血分数>40%且无心肌梗死病史的SHIP(波美拉尼亚健康研究)参与者的数据(年龄为21-82岁;中位年龄为49岁;53%为女性)。参与者接受了头部的超声心动图和磁共振成像检查。脑衰老的成像标志物(即CT和WMH体积)由磁共振成像扫描结果来确定。

LV质量和直径与较低的整体CT和较大的WMH体积相关,同时调整年龄、性别、身高、无脂肪体重和颅内体积。此外,室间隔和后壁的厚度也与较低的整体CT相关。这些关联不能用心血管危险因素(包括高血压)、炎症标志物或社会人口学因素来解释。

由此可见,LV直径和质量与较低的整体和区域性CT以及一般人群中较大的WMH负担相关。这些结果突出了LV肥大与认知能力下降和痴呆之间相关性的大脑结构基础。

原始出处:

Stefan Frenzel.et al.Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.020994

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    2021-09-03 zhaohui6731
  4. [GetPortalCommentsPageByObjectIdResponse(id=2026110, encodeId=2d982026110ad, content=<a href='/topic/show?id=15a68512622' target=_blank style='color:#2F92EE;'>#脑衰老#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85126, encryptionId=15a68512622, topicName=脑衰老)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Wed Dec 29 04:53:05 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635391, encodeId=2277163539115, content=<a href='/topic/show?id=0a424396536' target=_blank style='color:#2F92EE;'>#大脑衰老#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43965, encryptionId=0a424396536, topicName=大脑衰老)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=efe722453549, createdName=ms3323097325231039, createdTime=Mon Aug 15 11:53:05 CST 2022, time=2022-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268620, encodeId=ce3c1268620c3, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Sep 03 14:53:05 CST 2021, time=2021-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1013755, encodeId=fa751013e5586, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c7351359550, createdName=372293, createdTime=Thu Sep 02 13:42:40 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1013633, encodeId=b6cf1013633fc, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bc755591863, createdName=ms8000000623347486, createdTime=Thu Sep 02 01:22:40 CST 2021, time=2021-09-02, status=1, ipAttribution=)]
    2021-09-02 372293

    嗯嗯

    0

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    2021-09-02 ms8000000623347486

    不错

    0

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