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Int Arch Allergy Immunol:毛茸动物敏感以及与屋尘螨诱导的过敏性鼻炎临床相关性

2020-06-17 AlexYang MedSci原创

毛茸动物过敏原对屋尘螨(HDM)诱导的过敏性鼻炎(AR)的影响仍不清楚。最近,有研究人员调查了毛茸动物过敏原的共敏感和交叉敏感以及与HDM诱导的AR之间的临床相关性。

毛茸动物过敏原对屋尘螨(HDM)诱导的过敏性鼻炎(AR)的影响仍不清楚。最近,有研究人员调查了毛茸动物过敏原的共敏感和交叉敏感以及与HDM诱导的AR之间的临床相关性。

研究包括了268名HDM诱导的AR患者,且对狗和/或猫过敏原皮刺测试为阳性。研究发现,AR和哮喘(AS;n=166),轻度到中度永久性AR(n=132)和e1P-e2P(n=89)组的VAS评分均比单一AR(n=102)、其他AR分类和其他敏感情况更高。组分的lgE阳性率,比如Can f 1-3和Fel d 2以及大鼠、绵羊、小鼠、牛和马的组分在e1P-e2P组患者中最高。Can f 1-4、Fel d 1、Fel d 2或者其他联合过敏原与VAS评分呈现正相关关系。AR和AS,对Can f 4、Fel d 1和小鼠敏感均是VAS评分不小于5的HDM诱导AR患者的风险因子。

最后,研究人员指出,他们在Can f1 -3、Fel d2、或大鼠、绵羊、小鼠、牛和马提取物中发现了大量的交叉敏感和共敏感。更高水平的Can f1 -4和Fel d 1-2 slgE水平或者更多的毛茸动物过敏原数量将会导致更加严重的症状并减少生活质量。结合AS,对Can f 4和Fel d 1以及小鼠敏感均是中度到重度HDM诱导AR的风险因子。

原始出处:

Hao Chen , Zhifeng Huang , Wenting Luo et al. Sensitization to Furry Animals and Clinical Relevance of House Dust Mite-Induced Allergic Rhinitis in Guangzhou, China. Int Arch Allergy Immunol. 09 Jun 2020.

 

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    2020-06-19 膀胱癌
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