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MBio：InlJ和Als3介导牙龈卟啉单胞菌和白色念珠菌菌落形成

2018-05-08 MedSci MedSci原创

InlJAls3牙龈卟啉单胞菌白色念珠菌
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多形酵母白色念珠菌是感染免疫缺陷患者的一种重要病原体。在口腔中，白色念珠菌参与多微生物群落的形成，且种间相互作用促进了菌丝形成和生物膜形成。白色念珠菌定植在龈下区域，牙周病位点的定植频率增加。本研究中，研究人员探究了白色念珠菌和牙周致病菌牙龈卟啉单胞菌之间的相互作用。结果发现，白色念珠菌和牙龈卟啉单胞菌在浮游阶段和附着阶段共存。内因子家族蛋白InlJ的丧失废除了牙龈卟啉单胞菌与白色念珠菌的粘附，且

多形酵母白色念珠菌是感染免疫缺陷患者的一种重要病原体。在口腔中，白色念珠菌参与多微生物群落的形成，且种间相互作用促进了菌丝形成和生物膜形成。白色念珠菌定植在龈下区域，牙周病位点的定植频率增加。本研究中，研究人员探究了白色念珠菌和牙周致病菌牙龈卟啉单胞菌之间的相互作用。

结果发现，白色念珠菌和牙龈卟啉单胞菌在浮游阶段和附着阶段共存。内因子家族蛋白InlJ的丧失废除了牙龈卟啉单胞菌与白色念珠菌的粘附，且重组InlJ蛋白竞争性地抑制种间结合。主要菌丝蛋白Als3表达缺陷的白色念珠菌突变体显示与牙龈卟啉单胞菌的结合减少，且InlJ与酿酒酵母中异源表达的Als3相互作用通过RNA测序（RNA-Seq）转录分析确定了57个基因以InIJ依赖的方式独特在牙龈卟啉单胞菌-白色念珠菌中上调。与疾病过程潜在相关，白色念珠菌诱导IX型分泌装置组分的上调。

总的来说，这些发现表明，InlJ-Als3依赖性结合促进了白色念珠菌和牙龈卟啉菌之间的结构域间发育，并且牙龈卟啉菌可能会增加这些群体内的毒力。

原始出处：

Sztukowska MN, Dutton LC, et al., Community Development between Porphyromonas gingivalis and Candida albicans Mediated by InlJ and Als3. MBio. 2018 Apr 24;9(2). pii: e00202-18. doi: 10.1128/mBio.00202-18.

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    2019-02-07 tigerlr107

    #念珠菌#

    0

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    2019-04-24 sunylz

    #Bio#

    0

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    2019-02-22 h.y200607_23674425

    #白色念珠菌#

    0

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    2018-09-11 dangious

    #Als3#

    0

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    2018-05-10 3631173

    #牙龈卟啉单胞菌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1670589, encodeId=eeb716e0589b5, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Thu Feb 07 04:51:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918075, encodeId=f24519180e550, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Apr 24 01:51:00 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635981, encodeId=eb4e1635981c3, content=<a href='/topic/show?id=3ed6e1757c0' target=_blank style='color:#2F92EE;'>#白色念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71757, encryptionId=3ed6e1757c0, topicName=白色念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e97b22549620, createdName=h.y200607_23674425, createdTime=Fri Feb 22 01:51:00 CST 2019, time=2019-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779697, encodeId=e9b31e79697af, content=<a href='/topic/show?id=cd0a236804' target=_blank style='color:#2F92EE;'>#Als3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2368, encryptionId=cd0a236804, topicName=Als3)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ce4238, createdName=dangious, createdTime=Tue Sep 11 13:51:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361051, encodeId=cfd7136105189, content=<a href='/topic/show?id=c1006e72663' target=_blank style='color:#2F92EE;'>#牙龈卟啉单胞菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67726, encryptionId=c1006e72663, topicName=牙龈卟啉单胞菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7a159, createdName=3631173, createdTime=Thu May 10 04:51:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313181, encodeId=7644313181a4, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue May 08 15:12:41 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
    2018-05-08 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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