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GUT：不同筛查方法对间期结肠癌风险的影响

2018-06-25 zhangfan MedSci原创

间期结肠癌愈创木酚粪便隐血试验粪便免疫化学试验
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研究认为，愈创木酚粪便隐血试验阴性人群的间期结肠癌风险显著低于粪便免疫化学试验阴性人群

粪便免疫化学试验(FITs)及愈创木酚粪便隐血试验(gFOBTs)均是现行的结肠癌筛查方法，近日研究人员比较了FIT或gFOBT阴性人群间期结直肠癌(iCRC)发病率的差异。

本次研究为系统综述及荟萃分析研究，考察截止2017年12月的相关研究数据。研究的主要终点为每100000患者年(p-y)中iCRC的发病率。

29个研究，总计6987825个样本纳入本次研究，总计11932名患者参与结肠癌筛查。以每克粪便样本中中位粪便血红蛋白(Hb)含量20？g 为检测限。每100000患者年中，FIT及gFOBT阴性人群，间期结肠癌发病20和34例。敏感性分析显示，FIT vs gFOBT的累积结肠癌发病率分别为0.58和0.36。FIT每发现1例iCRC患者，若采用gFOBT法可发现2.6例。60岁以下人群及第三轮筛查可显著降低iCRC风险。

研究认为，愈创木酚粪便隐血试验阴性人群的间期结肠癌风险显著低于粪便免疫化学试验阴性人群。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2042429, encodeId=e70820424292d, content=<a href='/topic/show?id=9f0ae59339a' target=_blank style='color:#2F92EE;'>#筛查方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75933, encryptionId=9f0ae59339a, topicName=筛查方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Oct 13 21:22:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061758, encodeId=ab742061e580c, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed May 08 03:22:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326912, encodeId=8b53326912a9, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Mon Jun 25 15:55:53 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326897, encodeId=d3f232689e7d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Jun 25 13:45:53 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-10-13 soongzhihua

    #筛查方法#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2042429, encodeId=e70820424292d, content=<a href='/topic/show?id=9f0ae59339a' target=_blank style='color:#2F92EE;'>#筛查方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75933, encryptionId=9f0ae59339a, topicName=筛查方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Oct 13 21:22:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061758, encodeId=ab742061e580c, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed May 08 03:22:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326912, encodeId=8b53326912a9, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Mon Jun 25 15:55:53 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326897, encodeId=d3f232689e7d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Jun 25 13:45:53 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2019-05-08 sjq027

    #癌风险#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2042429, encodeId=e70820424292d, content=<a href='/topic/show?id=9f0ae59339a' target=_blank style='color:#2F92EE;'>#筛查方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75933, encryptionId=9f0ae59339a, topicName=筛查方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Oct 13 21:22:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061758, encodeId=ab742061e580c, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed May 08 03:22:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326912, encodeId=8b53326912a9, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Mon Jun 25 15:55:53 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326897, encodeId=d3f232689e7d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Jun 25 13:45:53 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-06-25 wqkm

    ^_^^_^^_^^_^

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2042429, encodeId=e70820424292d, content=<a href='/topic/show?id=9f0ae59339a' target=_blank style='color:#2F92EE;'>#筛查方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75933, encryptionId=9f0ae59339a, topicName=筛查方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Oct 13 21:22:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061758, encodeId=ab742061e580c, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed May 08 03:22:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326912, encodeId=8b53326912a9, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Mon Jun 25 15:55:53 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326897, encodeId=d3f232689e7d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Jun 25 13:45:53 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-06-25 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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