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Chest:入住ICU时肌肉和脂肪量与患者出院时生存和残疾之间的关系

2018-10-29 xing.T MedSci原创

由此可见,在该队列中,入住ICU时PMA与严重疾病期间以及之后的生存相关,而无法预测出院后恢复独立的生活方式。入住ICU时的皮下脂肪组织质量与生存或其他测量结局无关。

由于入住重症监护室(ICU)而发生的骨骼肌功能障碍伴随着更高的死亡率。虽然入院前更高的体重指数(BMI)与更好的结局相关,但基线肌肉和脂肪量的影响尚未明确。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员调查了ICU入院时骨骼肌和脂肪量与出院时生存和残疾之间的关系。

研究人员对来自于美国学术机构的医疗重症监护病房(MICU)患者进行了单中心、前瞻性、观察性队列研究。在入住ICU时通过计算机断层扫描(CT)扫描对401名患者进行了胸大肌区域(PMA)和皮下脂肪组织(SAT)的评估,这些与随后考虑了潜在混杂因素的临床结局相关。

研究人员发现较大的入院PMA与更好的结局相关,包括更高的6个月生存率(OR为1.03; 95%CI为1.01-1.04; p<0.001)、更低的住院死亡率(OR为0.96; 95%CI为0.93-0.98; p<0.001),以及更多不入住ICU天数(斜率为0.044±0.019; p=0.021)。SAT与任何测量结局之间没有显著关联。在多变量分析中,PMA与存活与不入住ICU天数相关,而SAT与存活或其他结果无关。PMA与出院时恢复独立性无关(OR为0.99; 95%CI为0.98-1.01; p=0.56)。

由此可见,在该队列中,入住ICU时PMA与严重疾病期间以及之后的生存相关,而无法预测出院后恢复独立的生活方式。入住ICU时的皮下脂肪组织质量与生存或其他测量结局无关。

原始出处:

Ariel Jaitovich,et al.ICU admission muscle and fat mass, survival and disability at discharge: a prospective cohort study.chest.2018. https://journal.chestnet.org/article/S0012-3692(18)32645-X/fulltext

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    2019-02-03 Smile2680
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    2018-11-20 jyzxjiangqin

    肌肉和脂肪量的关系。

    0

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    2018-10-30 深海的鱼

    学习学习学习

    0

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    2018-10-29 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2018-10-29 天地飞扬

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