Br J Cancer：肿瘤酸中毒与乳腺癌的转移潜力相关

2020-12-09 xiaozeng MedSci原创

xiaozeng

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乳腺癌是全球女性中癌症相关死亡的第二大主要原因。癌症的远端转移仍是主要的死亡原因。在过去的几年中，由于筛查程序和早期诊断的增加，乳腺癌患者的转移和死亡率有所降低。

乳腺癌是全球女性中癌症相关死亡的第二大主要原因。癌症的远端转移仍是主要的死亡原因。在过去的几年中，由于筛查程序和早期诊断的增加，乳腺癌患者的转移和死亡率有所降低。

肿瘤酸中毒被认为在促进癌症侵袭和迁移中起着至关重要的作用，然而目前关于肿瘤pH与癌症侵袭能力相关性的研究较少。该研究旨在确定体内肿瘤的酸度是否与癌症的转移潜力相关。

TUBO、4T1和TS/A细胞的迁移和侵袭能力

研究人员通过肿瘤侵略性和侵袭性标志物分析几种乳腺癌细胞系的转移潜能。构建小鼠肿瘤模型并评估肺转移情况，并通过基于核磁共振成像（MRI）的化学交换饱和转移（CEST）pH成像方法评估体内肿瘤酸中毒。

4T1和TS/A表现出较强的酸性肿瘤环境

结果显示，相比于癌细胞侵袭性较低的TUBO和BALB-neuT原发性肿瘤细胞，4T1和TS/A原发性肿瘤细胞具有更高的转移潜力，该结果是通过癌细胞干性标志物（CD44+ CD24-）的高表达证实的，对应着肿瘤迁移和侵袭倾向。该结果也与体外测定的结果一致。MRI-CEST pH成像成功地区分了更具酸性的4T1和TS/A肿瘤。此外，研究人员观察到，较高的肿瘤酸度与肺转移数目的增加显著相关。

综上，该研究结果显示，细胞外酸化与癌症的转移潜能相关。

原始出处：

Anemone, A., Consolino, L., Conti, L. et al. Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential. Br J Cancer (01 December 2020).

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2021-05-23 hywen7335

#酸中毒#

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2020-12-13 胎胎

新颖的PH成像功能是发文的关键！

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2020-12-11 ms4000001839451027

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2020-12-10 ms6000000937098079

点赞

110 0
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2020-12-10 mashirong

#中毒#

85 0
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2020-12-10 122c47aem76暂无昵称

学习

131 0
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2020-12-09 1241e2cam13暂无昵称

赞👍

112 0
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2020-12-09 Jessie Zhang

细胞外酸化与癌症的转移潜能相关

52 0
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