Heart：CRT-D未产生额外生存获益

2014-04-04 高晓方译医学论坛网

英国一项研究表明，长期随访时心脏再同步治疗除颤器(CRT-D)未能产生额外生存获益。论文于4月1日在线发表于《心脏》(Heart)。此项研究共纳入500例置入心脏再同步治疗装置的患者，其中置入仅起搏装置(CRT-P)和CRT-D的患者分别为354和146例。随访时间至少为2年，平均随访29个月。主要终点为全因死亡率。结果显示，共记录116例(23.2%)死亡，CRT-P和CRT-D组分别为

英国一项研究表明，长期随访时心脏再同步治疗除颤器(CRT-D)未能产生额外生存获益。论文于4月1日在线发表于《心脏》(Heart)。

此项研究共纳入500例置入心脏再同步治疗装置的患者，其中置入仅起搏装置(CRT-P)和CRT-D的患者分别为354和146例。随访时间至少为2年，平均随访29个月。主要终点为全因死亡率。

结果显示，共记录116例(23.2%)死亡，CRT-P和CRT-D组分别为88和28例。第1年时CRT-D具有占优趋势，但第2年时趋势减弱，并在随访结束时失去统计学显著性。如果认为患者对CRT无应答，则内部心律转复除颤器不具有生存获益。在伴有缺血性心肌病的CRT-P组患者中，有27%具有潜在置入内部心律转复除颤器行一级预防的指征。对基线功能进行校正之后，两组患者之间无转归差异。

原始出处：

Looi KL1, Gajendragadkar PR, Khan FZ, Elsik M, Begley DA, Fynn SP, Grace AA, Heck PM, Virdee M, Agarwal S.Cardiac resynchronisation therapy: pacemaker versus internal cardioverter-defibrillator in patients with impaired left ventricular function.Heart. 2014 Apr 1. doi: 10.1136/heartjnl-2014-305537.

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2014-04-27 ms8538335253054589

#生存获益#

62 0
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2014-04-06 41514487@qq.com

#CRT#

58 0
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2014-04-06 zhaojie88

#ART#

53 0
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2014-04-06 minhuang75_72521587

#CRT-D#

56 0
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2014-04-06 爆笑小医

#HEART#

52 0

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