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J Endod:MTA促进人牙周膜再生成功的首例临床证据

2017-03-25 MedSci MedSci原创

这篇报道是为了验证MTA在应用于人牙髓治疗过程中,是否能像在动物模型中一样,可以促进根尖周组织的再生。

这篇报道是为了验证MTA在应用于人牙髓治疗过程中,是否能像在动物模型中一样,可以促进根尖周组织的再生。

在家庭诊所内,研究者对患者的4颗牙齿使用MTA实施根管治疗,随后这4颗牙齿在治愈后以非治疗失败的其他原因拔除并进行观察。所有拔除的牙齿进行组织学处理,随后观察和分析根尖周结构对MTA的组织学反应,其中一颗牙齿进行免疫组织化学分析。

结果显示,在拔除前,所有实施MTA治疗过的牙齿通过临床和放射线检查,均显示根尖愈合的体征。通过组织学观察发现,所有牙齿至少在MTA表面形成一层类似于牙骨质样结构。不仅如此,通过免疫荧光双标观察I型和III型胶原的表达以及表达重叠区域,发现有呈纤维状、类似于牙周膜样的组织形成。

结论:MTA促进人牙周膜的组织愈合符合在动物实验中发现的愈合模式。研究发现,MTA能够促使其表面形成牙骨质样结构,表明MTA可以促进牙周膜再生。

原始出处:

Bartols A Dr, Roussa E, et al. First Evidence for Regeneration of the Periodontium to Mineral Trioxide Aggregate in Human Teeth. J Endod. 2017 Mar 18. pii: S0099-2399(17)30006-7. doi: 10.1016/j.joen.2016.12.027.

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    2017-12-16 xqptu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1636086, encodeId=7cbe163608622, content=<a href='/topic/show?id=934b23012e9' target=_blank style='color:#2F92EE;'>#临床证据#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23012, encryptionId=934b23012e9, topicName=临床证据)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25622584555, createdName=more is better!, createdTime=Thu Aug 03 00:00:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755863, encodeId=33141e55863ef, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sat Dec 16 23:00:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185358, encodeId=49e218535866, content=M丅A总让牙体医生惊喜又感叹!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzbCrNlTIlTfsCoY1L9dvM1PibZhOWaeleTdib3jyTEEIppUnGkyuurLZ9ZCYNydgVQbNPicgTGASbJe/0, createdBy=cbaa2004663, createdName=山丫, createdTime=Wed Apr 05 17:48:06 CST 2017, time=2017-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368019, encodeId=658c136801956, content=<a href='/topic/show?id=de4912308e7' target=_blank style='color:#2F92EE;'>#MTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12308, encryptionId=de4912308e7, topicName=MTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sun Mar 26 15:00:00 CST 2017, time=2017-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450501, encodeId=50bc145050187, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Mar 26 15:00:00 CST 2017, time=2017-03-26, status=1, ipAttribution=)]
    2017-04-05 山丫

    M丅A总让牙体医生惊喜又感叹!

    0

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    2017-03-26 liuxiaona
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