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JACC:老人死亡风险的研究

2016-03-01 崔倩 译 MedSci原创

冠状动脉心脏病(冠心病)和卒中的成功预防和治疗,使寿命得到延长,但后续的老年痴呆症风险老年人口还会继续增长。作者评估了高领老年人冠状动脉和其他外周动脉粥样硬化的死亡,老年痴呆症和冠心病风险的关系。由于血管病变的程度在男性和女性中不同,所以该研究包括了性别和种族的具体分析,并且特别关注了低冠状动脉钙化(CAC) Agatston分数的女性。该心血管健康研究—认知研究在1998/1999年(平均年龄8

成功预防和治疗冠状动脉心脏病(冠心病)以及卒中,能使寿命得到延长,但在老年人口中,后续的老年痴呆症风险依然在继续增长。

作者评估了高领老人冠状动脉、其他外周动脉粥样硬化的死亡、老年痴呆症与冠心病风险的关系。由于血管病变的程度在男性和女性中不同,所以该研究包括了性别和种族的具体分析,并且特别关注了低冠状动脉钙化(CAC) Agatston分数的女性。

该心血管健康研究是一项认知研究,在1998/1999年(平均年龄80岁)到2012/2013年(平均年龄,93岁)之间进行,研究人员评估了532名参与者的亚临床心血管疾病(CAC、颈动脉内膜中层厚度、管腔狭窄和踝臂指数)和老年痴呆症、CHD以及总死亡率之间的关系。

36%的参与者CAC评分>400。女性和非裔美国人有较低的CAC分数。很少有男性有较低的CAC评分。 CAC评分和冠状动脉钙化的数量直接关系到年龄调整后总死亡率和冠心病。老年痴呆症的具体年龄发病率明显高于CHD。只有约25%的死亡是由冠心病引起的,16%是由痴呆造成的。死亡的参与者中大约有64%在之前被诊断为痴呆症。白人女性有较低的CAC评分,老年痴呆症发病率显著下降。

在80+岁的受试者中,老年痴呆症比冠心病的发生率更高。冠状动脉钙化,作为动脉粥样硬化的标记物,是死亡、冠心病和心梗风险的一个决定因素。白人女性有较低的CAC评分,有显著降低的老年痴呆症风险。特别是高龄老人存在着一个重要问题:预防动脉硬化及其并发症是否与更少的老年痴呆症和阿尔茨海默病有关,目前尚不知道。

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    2017-01-31 hbwxf
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    2016-03-05 忠诚向上

    关心老人

    0

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    2016-03-05 忠诚向上

    从我做起多关爱

    0

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