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Neuroradiology：动脉瘤相关血流逆向装置与金属延迟超敏反应的间的相关性

2017-09-18 shaosai MedSci原创

动脉瘤血流逆向超敏反应
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血流换向装置在复杂型巨大颅内动脉瘤的治疗中应用越来越广泛。然而，该术式多会引起较多的并发症，如动脉瘤的破裂。另外，血流逆向术后会引起局部管径减小而不伴内膜的增生。正前位看似"鱼嘴状"。本研究旨在探究血流换向装置与其金属延迟性超敏反应的相关性，并将结果发表在Neuroradiology上。

血流换向装置在复杂型巨大颅内动脉瘤的治疗中应用越来越广泛。然而，该术式多会引起较多的并发症，如动脉瘤的破裂。另外，血流逆向术后会引起局部管径减小而不伴内膜的增生。正前位看似"鱼嘴状"。本研究旨在探究血流换向装置与其金属延迟性超敏反应的相关性，并将结果发表在Neuroradiology上。本研究回顾性分析了2010年5月-2015年11月的患者记录。共有9例患者具有鱼嘴状换向装置。并纳入了25例志愿者。所有受试者进行前瞻性的皮肤过敏实验来验证对换向装置的超敏反应情况。利用Logistic回归分析和Wilcoxon秩和检验进行统计学分析。单变量和多变量分析来测试预测转向装置鱼嘴状形成的变量。转向装置发生鱼嘴样改变与阳性皮肤过敏试验间并没有统计学差异。在多变量分析中，过敏史和最大动脉瘤体积与转向装置发生鱼嘴样改变具有相关性。原始出处：Kocer N， Mondel PK， Yamac E ， et al，Is there an association between flow diverter fish mouthing and delayed-type hypersensitivity t

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    2017-10-28 shenxlcyp

    #相关性#

    0

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    2018-05-18 w984445tii

    #超敏反应#

    0

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    2017-09-19 半夏微凉

    学习了谢谢分享

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Sep 19 07:31:13 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245556, encodeId=0d6f2455561b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 19 06:53:21 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245529, encodeId=82b224552993, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Sep 19 05:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 shaosai

    好好学习.涨知识

    0

  5. 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    2017-09-19 tanxingdoctor

    学习啦!谢谢分享!

    0

  6. 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authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Sep 19 05:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 执着追梦

    学习.谢谢分享

    0

  7. 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authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Sep 19 05:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 meiliwuxian

    学习一下

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Sep 19 07:31:13 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245556, encodeId=0d6f2455561b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 19 06:53:21 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245529, encodeId=82b224552993, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Sep 19 05:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 忠诚向上

    好好看一下有意义

    0

  9. 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authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Sep 19 05:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 明月清辉

    谢谢分享.学习了

    0

  10. 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authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Sep 19 05:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 刘煜

    学习了.谢谢分享

    0

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慢性炎症在颅内动脉瘤的病理发生过程中起到关键作用。二肽基肽酶-4（DPP-4）抑制剂有抗炎症作用，包括阻止巨噬细胞浸润等。本次研究的主要目的是利用大鼠动脉瘤模型探索DPP-4抑制剂阿拉格列丁是否有抑制动脉瘤形成的作用。

Hypertension：血管周围脂肪组织血管紧张素II1型受体促进血管炎症和动脉瘤的形成

血管周围的脂肪组织具有活动性局部炎症的特征，这一特征有助于肥胖/代谢综合征的并发症动脉粥样硬化疾病的发展。然而，血管周围脂肪组织在腹主动脉瘤进展中的确切作用尚不清楚。近期，一项发表在杂志Hypertension上的研究探讨了血管紧张素内皮脂肪组织（VAT）中血管紧张素II型1a（AT1a）受体的遗传性缺失是否可以减轻载脂蛋白E缺陷型（ApoE-/- ）小鼠主动脉瘤的形成。研究者们使用血管紧张素II

Heart：BAV患者更易出现颅内动脉瘤

二叶主动脉瓣（BAV）是一种常见的先天性心脏病，长期不治疗可引起动脉瘤，包括颅内动脉瘤。近日，在国际心血管权威杂志《Heart》上发表了一篇旨在评估BAV患者颅内动脉瘤的发生率和预后的临床研究。本研究纳入了1994年至2013年在梅奥诊所行头颅磁共振的BAV患者，并回顾分析其临床资料。最终共纳入678名患者，平均年龄是57±13岁，男性占71%（480名），平均随访时间是10±3年。结果表明，有1

Stroke：动脉瘤破裂前后的形态变化

SAH降低了患者的生存年限的比例与缺血性卒中好脑出血相似。在正常人群中，颅内动脉瘤发生率大概为2-3.5%。SAH的80%病因为动脉瘤破裂。SAH发生率为10/10万人年，意味着大部分动脉瘤永远不会破裂。

上海新华医院吴震宇医生去世，年仅38岁

7月29日，华山医院抗感染专家李光辉教授因动脉瘤破裂，不幸离世。仅仅过去半个月，又一名医生离世了。上海新华医院甲状腺核医学科吴震宇医生于8月13日去世，年仅38岁。

Radiology：CTA作为后起之秀，斩杀颅内小动脉瘤于无形之利器！

随着影像学技术的发展，数字减影血管造影（DSA）仍然作为诊断大部分脑血管病变的金标准，而CT血管造影(CTA)在诊断颅内小动脉瘤方面发挥着越来越大的作用。研究人员通过进行了该项大样本队列研究，旨在以DSA为金标准，评估CTA血管造影在诊断5mm以下的脑动脉瘤的准确性。并将研究结果发表于放射学权威杂志Radiology上。

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