JAMA Netw Open：补充亚精胺对主观认知下降的老年人的认知和生物标志物的影响

2022-06-11 医路坦克 MedSci原创

针对与年龄相关的记忆力衰退和患有神经退行性疾病的老年人开发干预措施是我们这一代人面临的最大挑战之一。本文目的是确定长期补充亚精胺对该高危人群的记忆能力和生物标志物的影响。

针对与年龄相关的记忆力衰退和患有神经退行性疾病的老年人开发干预措施是我们这一代人面临的最大挑战之一。在动物模型中，亚精胺补充剂已经显示出对大脑和认知健康的有益作用，并且已经有初步证据表明主观认知下降的个体的记忆改善。

本文目的是确定长期补充亚精胺对该高危人群的记忆能力和生物标志物的影响。

这项为期12个月的随机、双盲、安慰剂对照的2b期试验(SmartAge试验)在2017年1月至2020年5月期间进行。这项研究是在德国的一个学术临床研究中心进行的单中心试验。符合条件的个体年龄在60到90岁之间，主观认知能力下降，他们是从卫生保健机构以及通过广告在普通人群中招募的。数据分析在2021年1月至3月间进行。

100名参与者被随机分配(1:1比例)进行为期12个月的膳食补充，使用从小麦胚芽中提取的富含亚精胺的膳食补充剂(0.9毫克亚精胺/天)，或使用安慰剂(微晶纤维素)。八十九名参与者(89%)成功完成了试验干预。

主要结果是从基线到干预后12个月评估(意向治疗分析)的记忆表现的变化，通过记忆相似性任务评估的记忆辨别表现进行操作。次要结果包括额外的神经心理学、行为学和生理学参数。对所有参与者进行安全性评估，并按照方案和亚组进行探索性分析。

共有100名参与者(亚精胺组51人，安慰剂组49人)纳入分析(平均[SD]年龄，69 [5]岁；49名女性参与者[49%])。超过12个月后，记忆辨别能力没有显著变化(组间差异为0.03；95%置信区间为0.11至0.05；P = .47)和次要结果。探索性分析表明干预对炎症和语言记忆可能有有益的影响。不良事件在组间平衡。

文献来源：Schwarz C, Benson GS, Horn N, Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.JAMA Netw Open 2022 May 02;5(5)

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2023-03-15 aids213

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2022-11-11 hukaixun

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2023-02-18 feather89

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2022-12-29 医者仁心

#NET#

84 0
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2022-05-31 doctorzheng

#亚精胺#

176 0
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2022-05-31 zhu_jun9842

#生物标志#

78 0
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2022-05-31 zhu_jun9842

#生物标志#

85 0
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2022-05-29 肿瘤克星

JAMA上文章都是顶级的，谢谢梅斯及时上新

73 0

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