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反流性食管炎内科综合治疗

2014-05-26 佚名 医学界

反流性食管炎(RE)是由胃、十二指肠内容物反流入食管引起的食管炎症性病变,内镜下表现为食管粘膜的破损,即食管糜烂和/或食管溃疡。临床表现主要为烧心、反流、胸痛及吞咽困难等。 反流性食管炎是消化系统常见病,主要由于食管抗反流机制减弱与反流物对食管黏膜攻击作用的结果,抗反流机制减弱包括下食管括约肌(LES)压降低或一过性LES松弛以及食管对反流物清除能力和食管黏膜抵抗能力下降,胃酸和胃蛋白酶是反流物

反流性食管炎(RE)是由胃、十二指肠内容物反流入食管引起的食管炎症性病变,内镜下表现为食管粘膜的破损,即食管糜烂和/或食管溃疡。临床表现主要为烧心、反流、胸痛及吞咽困难等。

反流性食管炎是消化系统常见病,主要由于食管抗反流机制减弱与反流物对食管黏膜攻击作用的结果,抗反流机制减弱包括下食管括约肌(LES)压降低或一过性LES松弛以及食管对反流物清除能力和食管黏膜抵抗能力下降,胃酸和胃蛋白酶是反流物中损害食管黏膜的主要成分。

奥美拉唑是H+-K+ATP酶抑制剂,是一种强有力的抑酸剂,在药物代谢动力学上表现为代谢率低,血浆浓度高的特点,可以抑制胃酸分泌。

莫沙比利是胃肠促动力药莫沙必利可改善LES功能状态及食管蠕动,协调胃十二指肠运动,改善胃肠动力,从而阻止胃食管反流及食管黏膜损害。

本文的研究发现,莫沙比利联合奥美拉唑内科综合治疗反流性食管炎的临床显效率为61.4%,总有效率达到88.6%,明显高于奥美拉唑单一治疗,且在无明显不良反应的发生,值得在临床中进一步推广。

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    2014-05-28 zhouqu_8
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    2014-05-28 feifers

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