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NEJM:“麻疹”之旅

2015-06-05 MedSci MedSci原创

一名54的女士作为传教士访问菲律宾后返回美国,随即出现了发热、咳嗽和流鼻涕的症状,持续了5天之久。既往她没有显著的临床病史,不记得自己以往是否有患过麻疹病史。但是,她称在自己小的时候,曾经全面接受过疫苗接种,其中包括麻疹疫苗。但药物的剂量和浓度已不明确。经体格检查发现,她的头部、颈部和肩膀部(如图A所示)等部位均出现了全身弥漫性分布的麻疹。在颊部黏膜上可见有白色的小丘疹(图B所示)。此外,该女士还

一名54的女士作为传教士访问菲律宾后返回美国,随即出现了发热、咳嗽和流鼻涕的症状,持续了5天之久。既往她没有显著的临床病史,不记得自己以往是否有患过麻疹病史。但是,她称在自己小的时候,曾经全面接受过疫苗接种,其中包括麻疹疫苗。但药物的剂量和浓度已不明确。
经体格检查发现,她的头部、颈部和肩膀部(如图A所示)等部位均出现了全身弥漫性分布的麻疹。在颊部黏膜上可见有白色的小丘疹(图B所示)。此外,该女士还出现了颈部淋巴结肿大和结膜炎症状,眼部有浆液性的分泌物渗出(如图C所示)。




实验室检查结果显示,该女士转氨酶升高、白细胞减少和血小板减少。血清学检测结果显示antirubeola IgM抗体滴度升高(为正常上限的4.4倍)和antirubeola IgG抗体滴度降低。根据以上的临床检查结果及其临床表现,高度怀疑其患上的是麻疹,该女士随后立即被进行空气隔离处理。

针对本案例中的患者表现出的麻疹所特有的症状,其又刚从麻疹高发地区旅行归来,即可怀疑其患上的是麻疹,对于麻疹,免疫力低下的人群需要注意保护性的隔离,而正在接种麻疹疫苗的人群也一样。

确诊后,该女士接受了支持性的治疗,大量补充维生素A,不久即康复出院。

原始出处:

Evelyn Lilly, Bhaskar Srivastava.Measles.N Engl J Med 2015; 372:2217June 4, 2015DOI: 10.1056/NEJMicm1407399

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    2015-07-15 皮肤小生

    惊讶同楼上

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=32835, encodeId=3eb932835bf, content=惊讶同楼上, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150715/IMG55A6458618E327245.jpg, createdBy=69501634546, createdName=皮肤小生, createdTime=Wed Jul 15 19:38:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26732, encodeId=01f226e3202, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355554, encodeId=3bad13555547f, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jun 07 06:18:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26157, encodeId=cf432615e79, content=为什么人家一个麻疹的报道也能发新英格兰杂志呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 06 13:04:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26139, encodeId=10c0261398b, content=连麻疹的个案都能上NEJM?, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c061611816, createdName=sumer, createdTime=Fri Jun 05 23:34:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26134, encodeId=a5fb2613424, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Fri Jun 05 21:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=)]
    2015-06-09 huaxipanxing

    ?

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=32835, encodeId=3eb932835bf, content=惊讶同楼上, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150715/IMG55A6458618E327245.jpg, createdBy=69501634546, createdName=皮肤小生, createdTime=Wed Jul 15 19:38:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26732, encodeId=01f226e3202, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355554, encodeId=3bad13555547f, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jun 07 06:18:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26157, encodeId=cf432615e79, content=为什么人家一个麻疹的报道也能发新英格兰杂志呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 06 13:04:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26139, encodeId=10c0261398b, content=连麻疹的个案都能上NEJM?, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c061611816, createdName=sumer, createdTime=Fri Jun 05 23:34:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26134, encodeId=a5fb2613424, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Fri Jun 05 21:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=)]
    2015-06-07 zhaojie88
  4. [GetPortalCommentsPageByObjectIdResponse(id=32835, encodeId=3eb932835bf, content=惊讶同楼上, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150715/IMG55A6458618E327245.jpg, createdBy=69501634546, createdName=皮肤小生, createdTime=Wed Jul 15 19:38:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26732, encodeId=01f226e3202, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355554, encodeId=3bad13555547f, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jun 07 06:18:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26157, encodeId=cf432615e79, content=为什么人家一个麻疹的报道也能发新英格兰杂志呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 06 13:04:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26139, encodeId=10c0261398b, content=连麻疹的个案都能上NEJM?, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c061611816, createdName=sumer, createdTime=Fri Jun 05 23:34:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26134, encodeId=a5fb2613424, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Fri Jun 05 21:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=)]
    2015-06-06 lovetcm

    为什么人家一个麻疹的报道也能发新英格兰杂志呢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=32835, encodeId=3eb932835bf, content=惊讶同楼上, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150715/IMG55A6458618E327245.jpg, createdBy=69501634546, createdName=皮肤小生, createdTime=Wed Jul 15 19:38:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26732, encodeId=01f226e3202, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355554, encodeId=3bad13555547f, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jun 07 06:18:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26157, encodeId=cf432615e79, content=为什么人家一个麻疹的报道也能发新英格兰杂志呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 06 13:04:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26139, encodeId=10c0261398b, content=连麻疹的个案都能上NEJM?, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c061611816, createdName=sumer, createdTime=Fri Jun 05 23:34:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26134, encodeId=a5fb2613424, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Fri Jun 05 21:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=)]
    2015-06-05 sumer

    连麻疹的个案都能上NEJM?

    0

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    2015-06-05 s312486

    学到了

    0

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美国梅奥诊所研究人员近日报告说,他们用超高剂量、经过处理的麻疹病毒“治愈”了一名美国妇女的晚期多发性骨髓瘤。不过,研究人员也强调,这一疗法仍处于人体试验的最初阶段。 据新一期《梅奥诊所学报》介绍,接受治疗前,这名49岁女性的癌变已经扩散至全身,其中前额长出一个直径3厘米的肿瘤。研究人员开发的麻疹病毒疗法会有选择性地杀灭骨髓瘤浆细胞。这名女性打过一针后即获得“完全缓解”,至今已保持了6个多月。

麻疹那些事:古老传染病重回视线

麻疹是儿童最常见的急性呼吸道传染病之一 最近两天,一种古老的传染病忽然间重新回到了人们的视线。 27日晚,北京市疾控中心通报,东城区某大厦暴发麻疹疫情,截至28日,北京共报告麻疹病例142例。数天前的22日,美国加州同样暴发麻疹疫情,其中42人被证实直接在迪斯尼乐园感染。 美国15年前就宣布已经消灭了麻疹,近日竟然卷土重来。我们每人小时候都接种过麻疹疫苗,而这次东城区

麻疹来袭:哪些是你应该知道的?

近期,美国出现了麻疹疫情,17个州出现了121名麻疹病人。中国多个省份也报道了麻疹病例。美国疾病控制与预防中心(CDC)近日刊文介绍麻疹的一些基本常识。 麻疹是一种高传染性疾病,常见于儿童,会对儿童造成很大伤害。父母应当确保子女及时接种麻疹疫苗。麻疹的最初症状是发热。随后引起咳嗽、流鼻涕、眼睛发红。然后皮肤出现大量的红疹。麻疹很可能引起肺炎、脑炎,甚至死亡。 麻疹是如何传播的? 麻疹可

NEJM:雾化吸入麻疹疫苗也是有效

麻疹是儿童最常见的急性呼吸道传染病之一,其传染性很强,是造成疾病和死亡的原因之一。通过雾化吸入方式接种麻疹疫苗,可以免却传统皮下注射针刺之痛等伤害,但是目前临床上关于儿童雾化吸入麻疹疫苗对麻疹的免疫原性数据不一致。因此Low N等人进行了一项研究以探究雾化吸入麻疹疫苗的有效性和安全性。

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