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Clin Otolaryngol:嗜酸粒细胞计数在诊断过敏性鼻炎伴慢性鼻窦炎中的作用如何?

2022-10-21 AlexYang MedSci原创

分析了有/无CRS的AR和NAR患者的血液参数差异。

慢性鼻炎分为过敏性鼻炎(AR)和非过敏性鼻炎(NAR)。两者都有类似的鼻部症状,如鼻塞、水样的鼻出血、打喷嚏和瘙痒。过敏性鼻炎(AR)和非过敏性鼻炎(NAR)常常与慢性鼻窦炎(CRS)并发。找到一种方便的检测方法来区分这些复杂的疾病有助于进行有效的治疗。

近期,来自湘雅医学院的研究人员在《Clin Otolaryngol》上发表文章,分析了有/无CRS的AR和NAR患者的血液参数差异。

研究共纳入了813名患者,包括了不同疾病情况的AR和NAR患者(有鼻息肉的CRS(CRSwNP)和没有鼻息肉的CRS(CRSsNP))。那些仅有鼻腔偏移的患者则列为健康对照组(HC)。研究人员采用了ROC分析来评估血液参数对诊断有无CRS的AR或NAR的价值。

研究结果发现,与非过敏性鼻炎(HC、CRSwNP和CRSsNP)相比,除NAR-CRSsNP(AR、AR-CRSwNP、AR-CRSsNP、NAR和NAR-CRSwNP)外,过敏性鼻炎组的血液嗜酸粒细胞数显著增加。NAR-CRSsNP组的嗜酸性粒细胞水平高于HC和CRSsNP组。在过敏性鼻炎患者中,患有CRSwNP(AR-CRSwNP和NAR-CRSwNP)的过敏性鼻炎患者的嗜酸细胞高于没有CRSwNP(AR、AR-CRsNP、NAR和NAR-CRsNP)的过敏性鼻炎患者。然而,在AR和NAR之间没有观察到血液中嗜酸性粒细胞的差异。在非过敏性鼻炎患者之间也没有差异。

另外,血液中的嗜酸性粒细胞比例也有类似的发现。此外,血液中的嗜酸性粒细胞比例是预测过敏性鼻炎的一个很好的指标,特别是带有CRSwNP的过敏性鼻炎。

过敏性鼻炎组和非过敏性鼻炎组的血液嗜酸粒细胞计数和嗜酸粒细胞比例

综上所述,血液嗜酸粒细胞计数和比例可能是过敏性鼻炎的良好诊断预测指标,但不能区分AR和NAR。该指标在预测CRSwNP的过敏性鼻炎中效果较好

 

原始出处:

Qiqi Luo, Siyi Zhou, Bo Yuan et al. Blood eosinophil count in the diagnosis of allergic-like rhinitis with chronic rhinosinusitis. Clin Otolaryngol. Oct 2022

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    2022-10-21 14712177m93暂无昵称

    学习学习学习学习

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2095253, encodeId=deeb2095253df, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210828/617715f97b324c10a7a7c71dfc1d12d5/9663f0622dc74f04903f949bd370aeca.jpg, createdBy=36dc5189013, createdName=14712177m93暂无昵称, createdTime=Fri Oct 21 20:25:47 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095249, encodeId=c6e0209524905, content=血液嗜酸粒细胞计数和比例可能是过敏性鼻炎的良好诊断预测指标,但不能区分AR和NAR。该指标在预测CRSwNP的过敏性鼻炎中效果较好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0ad1894147, createdName=ms1907128386112981, createdTime=Fri Oct 21 20:21:19 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095242, encodeId=dbae209524288, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Oct 21 19:51:32 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095239, encodeId=e9de209523904, content=认真学习~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfb41991958, createdName=xulv123, createdTime=Fri Oct 21 19:34:31 CST 2022, time=2022-10-21, status=1, ipAttribution=)]
    2022-10-21 ms1907128386112981

    血液嗜酸粒细胞计数和比例可能是过敏性鼻炎的良好诊断预测指标,但不能区分AR和NAR。该指标在预测CRSwNP的过敏性鼻炎中效果较好。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2095253, encodeId=deeb2095253df, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210828/617715f97b324c10a7a7c71dfc1d12d5/9663f0622dc74f04903f949bd370aeca.jpg, createdBy=36dc5189013, createdName=14712177m93暂无昵称, createdTime=Fri Oct 21 20:25:47 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095249, encodeId=c6e0209524905, content=血液嗜酸粒细胞计数和比例可能是过敏性鼻炎的良好诊断预测指标,但不能区分AR和NAR。该指标在预测CRSwNP的过敏性鼻炎中效果较好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0ad1894147, createdName=ms1907128386112981, createdTime=Fri Oct 21 20:21:19 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095242, encodeId=dbae209524288, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Oct 21 19:51:32 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095239, encodeId=e9de209523904, content=认真学习~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfb41991958, createdName=xulv123, createdTime=Fri Oct 21 19:34:31 CST 2022, time=2022-10-21, status=1, ipAttribution=)]
    2022-10-21 医鸣惊人

    认真学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2095253, encodeId=deeb2095253df, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210828/617715f97b324c10a7a7c71dfc1d12d5/9663f0622dc74f04903f949bd370aeca.jpg, createdBy=36dc5189013, createdName=14712177m93暂无昵称, createdTime=Fri Oct 21 20:25:47 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095249, encodeId=c6e0209524905, content=血液嗜酸粒细胞计数和比例可能是过敏性鼻炎的良好诊断预测指标,但不能区分AR和NAR。该指标在预测CRSwNP的过敏性鼻炎中效果较好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0ad1894147, createdName=ms1907128386112981, createdTime=Fri Oct 21 20:21:19 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095242, encodeId=dbae209524288, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Oct 21 19:51:32 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2095239, encodeId=e9de209523904, content=认真学习~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfb41991958, createdName=xulv123, createdTime=Fri Oct 21 19:34:31 CST 2022, time=2022-10-21, status=1, ipAttribution=)]
    2022-10-21 xulv123

    认真学习~~

    0

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