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JACC：非甾体类抗炎药可增加房颤患者出血和住院风险

2018-07-13 MedSci MedSci原创

心血管非甾体类抗炎药房颤出血
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非甾体类抗炎药（NSAIDs）是常见的药物，但可能增加潜在的出血和血栓形成风险。本研究的目的旨在量化NSAIDs在RE-LY临床试验中的作用。本研究是探究NSAIDs在RE-LY临床试验中作用的事后分析，比较了达比加群酯（DE）150mg和110mgBID与华法林对房颤患者的作用。在18113名RE-LY临床试验的患者中，有2279名患者在试验期间至少服用过1次NSAIDs。与服用非NSAIDs患

非甾体类抗炎药（NSAIDs）是常见的药物，但可能增加潜在的出血和血栓形成风险。本研究的目的旨在量化NSAIDs在RE-LY临床试验中的作用。

本研究是探究NSAIDs在RE-LY临床试验中作用的事后分析，比较了达比加群酯（DE）150mg和110mgBID与华法林对房颤患者的作用。在18113名RE-LY临床试验的患者中，有2279名患者在试验期间至少服用过1次NSAIDs。与服用非NSAIDs患者相比，服用NSAIDs患者发生主要出血事件的风险明显增高（[HR]： 1.68； 95% [CI]： 1.40 - 2.02； p < 0.0001），胃肠道出血事件明显增高（HR： 1.81； 95% CI： 1.35 - 2.43； p < 0.0001），卒中和系统性栓塞风险也明显增高（HR： 1.50； 95% CI： 1.12 - 2.01； p = 0.007），而心梗发生风险在两组患者间无明显差异（HR： 1.22； 95% CI： 0.77 - 1.93； p = 0.40）。另外，服用NSAIDs的患者住院率也会更高（HR： 1.64； 95% CI： 1.51 - 1.77； p < 0.0001）。

本研究结果显示，非甾体类抗炎药可增加房颤患者主要出血事件、卒中和住院风险。

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    2018-08-06 hbwxf

    #JACC#

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    2018-07-15 xiaotao112411

    学习学习学习

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    2018-07-15 xiaotao112411

    学习学习学习

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    2018-07-15 xiaotao112411

    学习学习学习

    0

  5. 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    2018-07-15 xiaotao112411

    学习学习学习

    0

  6. 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    2018-07-15 xiaotao112411

    学习学习学习

    0

  7. 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    2018-07-15 xiaotao112411

    学习学习学习

    0

  8. 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    2018-07-15 xiaotao112411

    学习学习学习

    0

  9. 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    2018-07-15 bluefate121

    #住院风险#

    0

  10. 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    2018-07-15 zhouqu_8

    #非甾体类抗炎药#

    0

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