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J Endod：使用三联抗生素溶液或氯己定配合氢氧化钙控制根尖周炎牙齿感染的效果比较：一项临床随机试验

2018-08-30 lishiting MedSci原创

抗生素溶液氢氧化钙根管消毒
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这项临床随机试验的目的是为了比较使用三联抗生素溶液(1 mg/mL)或氢氧化钙/氯己定糊剂的治疗方案作为原发性根尖周炎牙齿感染根管内的相互作用药物的抗菌效果。

这项临床随机试验的目的是为了比较使用三联抗生素溶液(1 mg/mL)或氢氧化钙/氯己定糊剂的治疗方案作为原发性根尖周炎牙齿感染根管内的相互作用药物的抗菌效果。研究使用往返式单根锉配合2.5%次氯酸钠冲洗，对罹患根尖周炎的单根牙齿根管预备。随后分别使用1 mg/mL的三联抗生素溶液(minocycline， metronidazole， and ciprofloxacin) (n = 24)或含有氢氧化钙糊剂的2%葡萄糖酸氯己定(n = 23)进行根管内封药1周。分别提取根管内基线水平(S1)、化学机械预备后(S2)和根管内封药后(S3)的样本。从临床样本中提取DNA，并通过16S ribosomal RNA gene-based定量聚合酶链式反应评估细菌减少的总量。结果显示，所有S1样本均含有细菌，并且在治疗后细菌的数量均明显下降(P < .01)。S2和S3的细菌水平在各组间没有显著性差异(P > .05)。抗菌组S2至S3的减少为97%，而氢氧化钙/氯己定组为39%；仅前者具有统计学差异(P < .01)。抗菌组的定量聚合酶链式反应阴性S3样本数量明显高于氢氧化钙

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    2019-07-20 lingaifan

    #临床随机试验#

    0

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    2018-09-01 ms6127405442416114

    #氯己定#

    0

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    2018-09-01 zhangbaojun

    #根尖周炎#

    0

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    2018-09-01 zhouqu_8

    #牙齿#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1797589, encodeId=70931e975894a, content=<a href='/topic/show?id=6a5623080d7' target=_blank style='color:#2F92EE;'>#临床随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23080, encryptionId=6a5623080d7, topicName=临床随机试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jul 20 18:39:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344615, encodeId=81ae1344615ea, content=<a href='/topic/show?id=37286409571' target=_blank style='color:#2F92EE;'>#氯己定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64095, encryptionId=37286409571, topicName=氯己定)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380217, encodeId=8ff3138021e8e, content=<a href='/topic/show?id=48786219204' target=_blank style='color:#2F92EE;'>#根尖周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62192, encryptionId=48786219204, topicName=根尖周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcae472, createdName=zhangbaojun, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430144, encodeId=224c143014429, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512148, encodeId=df481512148aa, content=<a href='/topic/show?id=cfd19846697' target=_blank style='color:#2F92EE;'>#随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98466, encryptionId=cfd19846697, topicName=随机试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c3710444656, createdName=124985dbm09(暂无昵称), createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569925, encodeId=85a215699252e, content=<a href='/topic/show?id=e14a6395908' target=_blank style='color:#2F92EE;'>#氢氧化钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63959, encryptionId=e14a6395908, topicName=氢氧化钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f315601930, createdName=tongyongming, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046609, encodeId=708d1046609d9, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Aug 30 12:39:00 CST 2018, time=2018-08-30, status=1, ipAttribution=)]
    2018-09-01 124985dbm09(暂无昵称)

    #随机试验#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1797589, encodeId=70931e975894a, content=<a href='/topic/show?id=6a5623080d7' target=_blank style='color:#2F92EE;'>#临床随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23080, encryptionId=6a5623080d7, topicName=临床随机试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jul 20 18:39:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344615, encodeId=81ae1344615ea, content=<a href='/topic/show?id=37286409571' target=_blank style='color:#2F92EE;'>#氯己定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64095, encryptionId=37286409571, topicName=氯己定)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380217, encodeId=8ff3138021e8e, content=<a href='/topic/show?id=48786219204' target=_blank style='color:#2F92EE;'>#根尖周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62192, encryptionId=48786219204, topicName=根尖周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcae472, createdName=zhangbaojun, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430144, encodeId=224c143014429, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512148, encodeId=df481512148aa, content=<a href='/topic/show?id=cfd19846697' target=_blank style='color:#2F92EE;'>#随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98466, encryptionId=cfd19846697, topicName=随机试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c3710444656, createdName=124985dbm09(暂无昵称), createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569925, encodeId=85a215699252e, content=<a href='/topic/show?id=e14a6395908' target=_blank style='color:#2F92EE;'>#氢氧化钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63959, encryptionId=e14a6395908, topicName=氢氧化钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f315601930, createdName=tongyongming, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046609, encodeId=708d1046609d9, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Aug 30 12:39:00 CST 2018, time=2018-08-30, status=1, ipAttribution=)]
    2018-09-01 tongyongming

    #氢氧化钙#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1797589, encodeId=70931e975894a, content=<a href='/topic/show?id=6a5623080d7' target=_blank style='color:#2F92EE;'>#临床随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23080, encryptionId=6a5623080d7, topicName=临床随机试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jul 20 18:39:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344615, encodeId=81ae1344615ea, content=<a href='/topic/show?id=37286409571' target=_blank style='color:#2F92EE;'>#氯己定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64095, encryptionId=37286409571, topicName=氯己定)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380217, encodeId=8ff3138021e8e, content=<a href='/topic/show?id=48786219204' target=_blank style='color:#2F92EE;'>#根尖周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62192, encryptionId=48786219204, topicName=根尖周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcae472, createdName=zhangbaojun, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430144, encodeId=224c143014429, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512148, encodeId=df481512148aa, content=<a href='/topic/show?id=cfd19846697' target=_blank style='color:#2F92EE;'>#随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98466, encryptionId=cfd19846697, topicName=随机试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c3710444656, createdName=124985dbm09(暂无昵称), createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569925, encodeId=85a215699252e, content=<a href='/topic/show?id=e14a6395908' target=_blank style='color:#2F92EE;'>#氢氧化钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63959, encryptionId=e14a6395908, topicName=氢氧化钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f315601930, createdName=tongyongming, createdTime=Sat Sep 01 00:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046609, encodeId=708d1046609d9, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Aug 30 12:39:00 CST 2018, time=2018-08-30, status=1, ipAttribution=)]
    2018-08-30 CHANGE

    疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

    0

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