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Diabetes Care:A1C和血糖对非心脏和心脏手术患者术后死亡率的影响!

2018-02-14 xing.T MedSci原创

由此可见,尽管A1C与围手术期血糖呈正相关,但控制血糖后,其与30天死亡率无关。围手术期血糖可预测30天死亡率,非心脏手术呈线性,心脏手术患者呈线性。这证实了围手术期血糖控制与手术疗效相关,但A1C反映前期血糖变化,是一个不太有用的预测指标。

糖化血红蛋白(A1C)用于评估择期手术患者,因为高血糖增加了不良事件的发生风险。然而,A1C、葡萄糖与手术治疗的效果之间的相互作用尚不清楚,这三个因素常常只是同时考虑两个。近日,糖尿病领域权威杂志Diabetes Care上发表了研究文章,研究人员评估了术前A1C与围手术期血糖控制之间的关系,及其与30天死亡率之间的相关性。

研究人员通过对杜克大学健康系统内431480例手术进行回顾性分析以确定术前A1C水平与围手术期血糖(在术后前3天的平均值)与30天死亡率之间的相关性,其中对6684例非心脏和6393例心脏手术患者进行A1C和血糖测量。研究人员使用广义相加模型来明确非线性关系。

研究人员发现A1C与葡萄糖密切相关。血糖与死亡率呈正相关,对于非心脏手术病例:平均血糖100mg/dL死亡率为1%,平均血糖200mg/dL死亡率为1.6%。对于心脏手术,血糖和死亡率之间存在显著的U型关系,从100mg/dL的4.5%到140mg/dL的最低值1.5%,再上升到200mg/dL的6.9%。当控制非心脏或心脏手术血糖时,A1C与30天死亡率不相关。

由此可见,尽管A1C与围手术期血糖呈正相关,但控制血糖后,其与30天死亡率无关。围手术期血糖可预测30天死亡率,非心脏手术呈线性,心脏手术患者呈线性。这证实了围手术期血糖控制与手术疗效相关,但A1C反映前期血糖变化,是一个不太有用的预测指标。

原始出处:

Willem van den Boom,et al. Effect of A1C and Glucose on Postoperative Mortality in Noncardiac and Cardiac Surgeries.Diabetes Care 2018. https://doi.org/10.2337/dc17-2232

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    2018-02-26 惠映实验室

    学习.谢谢分享.

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1760538, encodeId=49b31e605380d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 29 16:23:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819281, encodeId=bf57181928176, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Mon Feb 26 02:23:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638419, encodeId=84b21638419e2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Mar 15 00:23:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291156, encodeId=dc12291156ad, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Feb 26 19:53:18 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901979, encodeId=fb9019019e960, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Wed Jun 06 00:23:00 CST 2018, time=2018-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630999, encodeId=6af8163099943, content=<a href='/topic/show?id=105b610e30f' target=_blank style='color:#2F92EE;'>#术后死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61073, encryptionId=105b610e30f, topicName=术后死亡率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058c21623844, createdName=jiekemin, createdTime=Fri Feb 16 00:23:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287884, encodeId=b79728e88497, content=学习了涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Feb 14 11:14:28 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287880, encodeId=d58b28e880e9, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Feb 14 11:09:14 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 1ddf0692m34(暂无匿称)

    学习了涨知识

    0

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    2018-02-14 131****1460

    学习了受益匪浅

    0

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