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Sci Rep：靶向Wnt/β-连环蛋白通路或可促进骨再生

2017-09-27 MedSci MedSci原创

Wnt/β-连环蛋白骨再生
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大量的证据表明，Wnt /β-连环蛋白通路参与各种干细胞的成骨分化。然而，Wnt/β-连环蛋白通路在调节大鼠外胚层干细胞（EMSCs）成骨分化中的作用仍然是未知的，外胚层干细胞被认为是牙间充质干细胞的祖细胞。在本研究中，我们证实了核β-连环蛋白在EMSC成骨分化过程中表达升高。Wnt信号传导抑制剂IWR-1-endo抑制EMSC成骨分化，而Wnt信号激动剂SKL2001促进EMSC成骨分化。此外，

大量的证据表明，Wnt /β-连环蛋白通路参与各种干细胞的成骨分化。然而，Wnt/β-连环蛋白通路在调节大鼠外胚层干细胞（EMSCs）成骨分化中的作用仍然是未知的，外胚层干细胞被认为是牙间充质干细胞的祖细胞。


在本研究中，我们证实了核β-连环蛋白在EMSC成骨分化过程中表达升高。Wnt信号传导抑制剂IWR-1-endo抑制EMSC成骨分化，而Wnt信号激动剂SKL2001促进EMSC成骨分化。此外，在EMSC成骨分化过程中，低亲和力神经生长因子受体（LNGFR）的过表达进一步上调核β-连环蛋白。

进一步的实验表明，LNGFR过表达增强EMSC成骨分化，而LNGFR沉默则降低。此外，IWR-1-endo减弱LNGFR增强的EMSC成骨分化。

总的来说，我们的数据显示，LNGFR靶向Wnt/β-连环蛋白通路，并正调控EMSC成骨分化，提示Wnt /β-连环蛋白通路可能参与牙齿发育，靶向Wnt/β-连环蛋白通路可能在牙组织工程再生应用中存在巨大潜力。

原始出处：

Gang Li, Junyu Liu, et al., LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells. Sci Rep. 2017; 7: 11021. Published online 2017 Sep 8. doi: 10.1038/s41598-017-11555-9

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    2017-12-23 ms7899726347904398

    #β-连环蛋白#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1956384, encodeId=0724195638414, content=<a href='/topic/show?id=eafb192048e' target=_blank style='color:#2F92EE;'>#β-连环蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19204, encryptionId=eafb192048e, topicName=β-连环蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Dec 23 04:15:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472088, encodeId=4beb14e20880e, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Sep 29 10:15:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598582, encodeId=6c04159858236, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Fri Sep 29 10:15:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248280, encodeId=68b124828012, content=天天关注梅斯.天天签到.天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/17/d5be787205d0c34875ae55a61f49c17d.jpg, createdBy=2a762072202, createdName=路人甲115, createdTime=Wed Sep 27 21:08:15 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248275, encodeId=4fa92482e56e, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Sep 27 20:16:06 CST 2017, time=2017-09-27, status=1, ipAttribution=)]
    2017-09-29 lsj630

    #骨再生#

    0

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    2017-09-29 zhwj

    #WNT#

    0

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    2017-09-27 路人甲115

    天天关注梅斯.天天签到.天天学习

    0

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    2017-09-27 131****1460

    学习了受益匪浅

    0

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