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Dermatol Surg:早期点阵消融激光治疗皮肤癌切除后疤痕的效果

2023-04-27 MedSci原创 MedSci原创 发表于上海

尽管采用了谨慎而精确的手术技术,但全厚的手术伤口还是会造成疤痕。建议采取各种术后措施,来能尽量减少疤痕。

尽管采用了谨慎而精确的手术技术,但全厚的手术伤口还是会造成疤痕。建议采取各种术后措施,来能尽量减少疤痕。这些措施包括保持湿润的伤口环境、减少细菌负荷、限制伤口活动、尽量减少伤口张力、光保护、疤痕按摩、外用硅凝胶和注射类固醇。然而,尽管采取了这些基本措施,许多术后疤痕仍会造成重大困扰,并在手术后长期存在。点阵烧蚀激光换肤已被证明可以改善手术疤痕的最终美容外观,但最佳时机尚不清楚。近日,发表于Dermatol Surg的一项随机对照试验旨在比较在第0天和第14天进行的二氧化碳(CO2)点阵激光治疗的手术疤痕。

这项前瞻性、随机、分疤、医生盲法研究纳入30个肢体上的手术疤痕。疤痕的一半在第0天或第14天接受CO 2激光的治疗。疤痕评估在6个月时评估了患者的偏好,医生改良的曼彻斯特疤痕量表(MMSS)评分,以及组织学上的定量疤痕分析(分形维数[FD]和裂隙[L]分析)。

 

结果显示,患者评估(54%喜欢第0天的一侧,46%喜欢第14天的一侧,P=0.58)或医生评估(第0天的平均MMSS为8.4,第14天为8.7,P=0.28)没有显著差异。两种干预方法的分形维数相似(第0天平均为1.778,第14天为1.781,p=0.80)。两种干预方法的裂隙度相似(第0天平均为0.368,第14天平均为0.345,p=0.44)。

综上所述,该研究结果表明,术中CO2激光的效果不逊于第14天的激光换肤,用于手术疤痕治疗。需要进一步研究以评估在更广泛的解剖部位和皮肤类型上的最佳治疗时机。该研究的局限性包括6个月的研究时间框架和4名受试者失去随访。超过6个月的长期随访对于完全跟踪疤痕的发展轨迹是很有价值的;然而,其他研究报告指出,6个月内的疤痕评估与1年内的评估一样可靠。

 

原始出处:

 

Matthew J Lin, et al., Early Fractional Ablative Laser for Skin Cancer Excision Scars: A Randomized Split-Scar Study. Dermatol Surg. 2023 Apr 1;49(4):338-342.

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    2023-05-01 121bfa5am47暂无昵称 来自广东省

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    2023-04-27 医鸣惊人 来自山西省

    认真学习了

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