J Periodontal Res：广泛型牙周炎免疫应答相关基因的DNA甲基化谱

2020-06-28 MedSci原创 MedSci原创

DNA甲基化的表观遗传可能与炎症性疾病的发展有关。由于宿主反应在牙周炎发病机理中的重要作用，因此本研究的目的是调查与健康个体相比，广泛型牙周炎（GP）患者牙龈组织中与免疫反应相关的基因的甲基化谱。

DNA甲基化的表观遗传可能与炎症性疾病的发展有关。由于宿主反应在牙周炎发病机理中的重要作用，因此本研究的目的是调查与健康个体相比，广泛型牙周炎（GP）患者牙龈组织中与免疫反应相关的基因的甲基化谱。

收集20名GP患者和20名健康参与者的牙龈组织。提取基因组DNA并进行酶消化。在每组包含六个样本的库中，使用涉及应答免疫的基因进行了初步筛选。选择组间表现出不同甲基化水平的基因用于单个测定以进行验证。

阵列结果显示，两组中评估的大多数基因均未甲基化。与GP组相比，对照组中MALT1，LTB和STAT5基因呈现部分甲基化。使用大量样本（每组n = 20）进行的验证的实验证实，与对照组相比，GP组的STAT5甲基化程度较低（P <.001）。

广泛型牙周炎与STAT5基因的甲基化不足有关。还需要进一步的研究来评估这些发现对功能的影响。

原文出处：

Andrea Mara Azevedo，DNA methylation profile of genes related to immune response in generalized periodontitis. Journal of periodontal research, 2020 June. Doi: 10.1111/jre.12726

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2020-12-20 Zx胡医生

广泛硬牙周炎与STAT5基因甲基化不足有关#牙周炎#

182 0
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2021-02-17 feather89

#PE#

58 0
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2021-02-19 小华子

#相关基因#

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2020-06-30 clmlylxy

#免疫应答#

68 0
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2020-06-30 医者仁心

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