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临床笔记丨危及生命的药物相互作用

2015-01-15 佚名 用药助手

1、伊曲康唑+特非那定 特非那定说明书“禁忌与三唑类抗真菌药(如酮康唑、伊曲康唑等)、与某些大环内酯类抗生素如(克拉霉素、红霉素、竹桃霉素等)以及严重损伤肝脏功能的其他药物合用。”伊曲康唑说明书“已报道当使用本品超过推荐剂量时,与环孢菌素A、阿司咪唑和特非那丁有相互作用。这些药物若与本品同服时,应减少剂量。”  文献依据:SFDA药品说明书范本2、卡马西平+地尔硫卓&nbs

1、伊曲康唑+特非那定 


特非那定说明书“禁忌与三唑类抗真菌药(如酮康唑、伊曲康唑等)、与某些大环内酯类抗生素如(克拉霉素、红霉素、竹桃霉素等)以及严重损伤肝脏功能的其他药物合用。”伊曲康唑说明书“已报道当使用本品超过推荐剂量时,与环孢菌素A、阿司咪唑和特非那丁有相互作用。这些药物若与本品同服时,应减少剂量。”
 
文献依据:SFDA药品说明书范本

2、卡马西平+地尔硫卓 

地尔硫卓缓释片说明书“本品与卡马西平合用后,一些病例中可使卡马西平的血药浓度增高40-72%而导致毒性。” 

文献依据:SFDA药品说明书范本

3、克拉霉素+麦角胺 

麦角胺咖啡因逾量可引起严重中毒,急性中毒症状为精神错乱、共济失调、惊厥、手足灰白发冷、感觉障碍,甚至因昏迷与呼吸麻痹而死亡。克拉霉素“与其他大环内酯类抗生素相似,本品会升高需要经过细胞色素P450系统代谢的药物的血清浓度(如阿司咪唑、华法林、麦角生物碱、三唑仑、咪达唑仑、环孢素、奥美拉唑、雷尼替丁、苯妥因、溴隐亭、阿芬他尼、海索比妥、丙吡胺、洛伐他汀、他克莫司等)。”
 
文献依据:SFDA药品说明书范本

4、环磷酰胺+吲哚美辛 

NSAID可增加抗利尿激素的分泌,两药联用可能导致急性水中毒,必要时进行监测。其他非甾体抗炎药也可能发生相似的相互作用。 

文献依据:汤光.药物相互作用速查手册[M].北京:化学工业出版社,2005.233~234.

5、依那普利+别嘌醇 

别嘌醇与血管紧张素转换酶抑制药类降压药和氨氯地平等合用,可引起史-约综合征(Stevens-Johnson syndrome)和皮疹等过敏反应。 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.937~938.

6、洛伐他汀+吉非罗齐 

吉非罗齐片说明书“氯贝丁酸衍生物与羟甲戊二酰辅酶A还原酶抑制剂,如洛伐他汀等合用治疗高脂血症,将增加两者严重肌肉毒性发生的危险,可引起肌痛、横纹肌溶解、血肌酸磷酸激酶增高等肌病,应尽量避免联合使用。”
文献依据:SFDA药品说明书范本

7、甲氨蝶呤+萘普生 

甲氨蝶呤“与部分非甾体类抗炎药联用,有突发严重甚至致命性骨髓抑制和胃肠毒性的报道。”萘普生“可升高甲氨蝶呤的血药浓度,从而增强其毒性(白细胞减少、血小板减少、贫血、中毒性肾损害和粘膜溃疡形成)。” 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.342~344,1341~1343.

8、对乙酰氨基酚+华法林 

华法林个体差异较大,治疗期间应严密观察病情,并依据凝血酶原时间INR值调整用量。增强本品抗凝作用的药有:阿司匹林、水杨酸钠、胰高血糖素、奎尼丁、吲哚美辛、保泰松、奎宁、利尿酸、甲磺丁脲、甲硝唑、别嘌呤醇、红霉素、氯霉素、某些氨基糖苷类抗生素、头孢菌素类、苯碘达隆、西米替丁、氯贝丁酯、右旋甲状腺素、对乙酰氨基酚等。

文献依据:SFDA药品说明书范本

9、胺碘酮+地高辛 

胺碘酮“增加血清地高辛浓度,亦可能增高其它洋地黄制剂的浓度达中毒水平,当开始用本品时洋地黄类药应停药或减少50%,如合用应仔细监测其血清中药浓度。本品有加强洋地黄类药对窦房结及房室结的抑制作用。” 

文献依据:SFDA药品说明书范本

10、卡马西平+红霉素 

卡马西平缓释片“烟酰胺、抗抑郁药、大环内酯类抗生素、异烟肼、西咪替丁等药物均可使本品血浓度升高,可出现毒性反应。”
文献依据:药品说明书范本

11、西咪替丁+美沙酮 

西咪替丁可使卡马西平、美沙酮、他克林的血药浓度升高,有导致药物过量的危险。
文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.711~714.

12、环丙沙星+茶碱 

环丙沙星与茶碱类合用时可能由于与细胞色素P450结合部位的竞争性抑制,导致茶碱类的肝消除明显减少,血消除半衰期(t1/2β)延长,血药浓度升高,出现茶碱中毒症状,如恶心、呕吐、震颤、不安、激动、抽搐、心悸等,故合用时应测定茶碱类血药浓度和调整剂量。
文献依据:SFDA药品说明书范本

13、雷尼替丁+麻醉椒 
 
资料缺

14、环孢素+地尔硫卓 

环孢素与雌激素、雄激素、西咪替丁、地尔硫卓、红霉素、酮康唑等合用,可增加本品的血浆浓度。因而可能使本品的肝、肾毒性增加。故与上述各药合用时须慎重,应监测患者的肝、肾功能及本品的血药浓度。 

文献依据:SFDA药品说明书范本

15、地高辛+阿普唑仑 

阿普唑仑“与地高辛合用,可增加地高辛血药浓度而致中毒。”
文献依据:SFDA药品说明书范本

16、地高辛+红霉素 

红霉素“与地高辛合用会增加后者的血药浓度,甚至达到中毒水平。建议要进行临床与心电图监测,必要时要调整地高辛的用量。” 

文献依据:SFDA药品说明书范本

17、地高辛+伊曲康唑 

伊曲康唑“已报道本品与华法林和地高辛有相互作用。因此这些药物若与本品同服时,应减少剂量。”伊曲康唑(斯皮仁诺)“在使用本品治疗期间需监测血浆浓度、药物作用及副作用的药物,当与伊曲康唑合用时,必要时应当减量:地高辛(通过抑制P-糖蛋白)。”

文献依据:SFDA药品说明书范本

18、地高辛+奎尼丁 

地高辛“与奎尼丁同用,可使本品血药浓度提高约一倍,提高程度与奎尼丁用量相关,甚至可达到中毒浓度,即使停用地高辛,其血药浓度仍继续上升,这是奎尼丁从组织结合处置换出地高辛,减少其分布容积之故。两药合用时应酌减地高辛用量1/2~1/3。” 

文献依据:SFDA药品说明书范本

19、布洛芬+锂盐 

锂盐的治疗指数低,治疗量和中毒量较接近。碳酸锂“与非甾体抗炎药〔如布洛芬、吲哚美辛)、乙醇和大多数抗精神病药合用,可使血锂浓度升高,增加锂的毒性。”
文献依据:《中国国家处方集》编委会.中国国家处方集.化学药品与生物制品卷[S].北京:人民军医出版社,2010.963.

20、甲氨蝶呤+复方磺胺甲噁唑 

甲氨蝶呤“与保泰松和磺胺类药物同用后,因与蛋白质结合的竞争,可能会引起本品血清浓度的增高而导致毒性反应的出现。”甲氧苄啶“不宜与抗肿瘤药、2,4-二氨基嘧啶类药物同时应用,也不宜在应用其他叶酸拮抗药物治疗的疗程之间应用本品。因为有产生骨髓再生不良或巨幼红细胞贫血的可能。” 

文献依据:SFDA药品说明书范本

21、美托洛尔+氟西汀 

氟西汀可引起美托洛尔的血药浓度升高,毒性增大,故应注意监测,必要时减少美托洛尔的用量。 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.499~502.

22、咪达唑仑+舒芬太尼 

咪达唑仑与芬太尼或舒芬太尼同用,可引起严重呼吸抑制及突然低血压,因而这些药合用时应严密监测血药浓度,并且适当减少剂量。
文献依据:《新编临床用药参考》

23、硝苯地平+镁 

镁剂用于早产治疗时,如与本药合用可引起显著的低血压和神经肌肉阻滞。合用时应密切监测血压。 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.577~580.

24、诺氟沙星+茶碱 

诺氟沙星“与茶碱类合用时可能由于与细胞色素P450结合部位的竞争性抑制,导致茶碱类的肝清除明显减少,血消除半衰期(t1/2β)延长,血药浓度升高,出现茶碱中毒症状,如恶心、呕吐、震颤、不安、激动、抽搐、心悸等,故合用时应测定茶碱类血药浓度和调整剂量。”
文献依据:SFDA药品说明书范本

25、苯妥英+胺碘酮 

胺碘酮可以抑制苯妥英肝代谢,升高苯妥英血清浓度,以致产生运动失调、眼球震颤、视觉模糊和双腿无力。需监测病人苯妥英水平,必要时调整其剂量。胺碘酮同其他乙内酰脲类抗惊厥药物同用有类似的相互作用。 

文献依据:汤光.药物相互作用速查手册[M].北京:化学工业出版社,2005.90.

26、苯妥英+氯霉素 

苯妥英钠“与氯霉素、异烟肼、保泰松、磺胺类合用可能降低本品代谢使血药浓度增加,增加本品的毒性。” 

文献依据:SFDA药品说明书范本

27、苯妥英+西咪替丁
西咪替丁“与苯妥英钠或其他乙内酰脲类合用,可能使后者的血药浓度增高,导致苯妥英钠中毒,必须合用时,应在5天后测定苯妥英钠血药浓度以便调整剂量,并注意定期复查周围血象。”
文献依据:SFDA药品说明书范本

28、普萘洛尔+氟西汀 

氟西汀可使普萘洛尔血药浓度升高,毒性增大,故应监测普萘洛尔的毒性反应,必要时减少用量。 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.493~496.

29、罗红霉素+地高辛 

罗红霉素与地高辛同用,可清除肠道中能灭活地高辛的菌群,导致体内地高辛降解减少,使地高辛血药浓度升高而发生毒性反应,两者合用时应监测心电图和血清强心苷水平。 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.144~145.

30、索他洛尔+地尔硫卓 

索他洛尔与钙通道阻滞药(如维拉帕米、地尔硫卓)合用,两者对房室传导和心室功能的影响有累加作用,合用时可加重传导阻滞,进一步抑制心室功能、降低血压,引起低血压、心动过缓、传导障碍和心力衰竭,应避免合用。 

文献依据:卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团,重庆出版社,2009.478~480.

31、链霉素+泮库溴铵 

链霉素与神经肌肉阻滞剂合用,可加重神经肌肉阻滞作用,导致肌肉软弱、呼吸抑制或呼吸麻痹(呼吸暂停)。 

文献依据:SFDA药品说明书范本

32、布洛芬+芬太尼   

资料缺

33、红霉素+西咪替丁
 
西咪替丁升高红霉素的血浆药物浓度(增加毒性发生的危险,其中包括耳聋)。
文献依据:《国家处方集》929页

34、维拉帕米+普萘洛尔 

与β-受体阻滞剂联合使用, 可增强对房室传导的抑制作用。钙拮抗剂合用,特别是静脉注射维拉帕米,要十分警惕本品对心肌和传导系统的抑制。 

文献依据:SFDA药品说明书范本

35、克拉霉素+麦角胺 

与其他大环内酯类抗生素相似,本品会升高需要经过细胞色素P450系统代谢的药物的血清浓度(如阿司咪唑、华法林、麦角生物碱、三唑仑、咪达唑仑、环孢素、奥美拉唑、雷尼替丁、苯妥因、溴隐亭、阿芬他尼、海索比妥、丙吡胺、洛伐他汀、他克莫司等)。逾量可引起严重中毒,急性中毒症状为精神错乱、共济失调、惊厥、手足灰白发冷、感觉障碍,甚至因昏迷与呼吸麻痹而死亡。 

文献依据:SFDA药品说明书范本

36、噻氯匹定+苯妥英钠 

正在接受苯妥英治疗的病人加用噻氯匹定后,苯妥英血药浓度升高,并产生毒性反应。应当仔细监测苯妥英血药浓度的变化,并注意观察是否有毒性反应出现。噻氯匹定至少抑制两种细胞色素P-450酶系统。已知苯妥英的代谢途径包括细胞色素P-450 2C9/10和细胞色素P-450 2C19。故推测,噻氯匹定可能抑制细胞色素P-450 2C19。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
    2015-01-27 lxyzzj

    药物相互作用经常被医生忽视。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
    2015-01-17 ylz8405
  4. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
    2015-01-15 gongzuozhong

    多谢,收藏了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
    2015-01-15 MedSci客户端网友

    厉害!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1909178, encodeId=be3919091e8d9, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Wed Aug 19 00:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14733, encodeId=7a8d14e33b0, content=药物相互作用经常被医生忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/woXbIlxICLCNmd2Vff8VnDuwUxlOMbsZib5582RE8Vt2kJ4NicZ9aickjKsiavbFM7iccsBjLXiaACaUeicwS81xKWQnA/132, createdBy=0d1e108758, createdName=lxyzzj, createdTime=Tue Jan 27 01:25:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471505, encodeId=6d0314e1505ef, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585010, encodeId=efa41585010bf, content=<a href='/topic/show?id=61888e8231b' target=_blank style='color:#2F92EE;'>#药物相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87823, encryptionId=61888e8231b, topicName=药物相互作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d4517099766, createdName=liao1625, createdTime=Sat Jan 17 02:35:00 CST 2015, time=2015-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14379, encodeId=d11d143e9ce, content=多谢,收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Thu Jan 15 15:34:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14373, encodeId=0d28143e392, content=厉害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Thu Jan 15 14:21:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14365, encodeId=5b2614365eb, content=有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.226.156.**, createdTime=Thu Jan 15 11:58:00 CST 2015, time=2015-01-15, status=1, ipAttribution=)]
    2015-01-15 116.226.156.**

    有用!

    0

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