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Hypertension:肾功能稍一下降,心脏病风险就增加,正常人亦是

2016-01-13 Mechront 译 MedSci原创

众所周知,肾脏疾病会导致心脏疾病风险增加。根据美国心脏协会杂志Hypertension上的最新研究显示,即使是肾脏功能下降程度很小,也会导致心脏和血管的损伤。该研究作者Jonathan Townend博士说:“即使是非常健康的人,只要肾功能稍微下降或低于正常,就会导致左心室质量的增加,进而导致心脏更硬损害其收缩舒张功能。”他说:“轻度慢性肾脏疾病很常见,目前影响了超过10%的美国民众;如果肾脏疾病

众所周知,肾脏疾病会导致心脏疾病风险增加。根据美国心脏协会杂志Hypertension上的最新研究显示,即使是肾脏功能下降程度很小,也会导致心脏和血管的损伤。

该研究作者Jonathan Townend博士说:“即使是非常健康的人,只要肾功能稍微下降或低于正常,就会导致左心室质量的增加,进而导致心脏更硬损害其收缩舒张功能。”他说:“轻度慢性肾脏疾病很常见,目前影响了超过10%的美国民众;如果肾脏疾病是心脏疾病的危险因素,那么意味着当前存在一个主要的公共健康问题。”不过由于肾脏疾病患者一般都有其他的危险因素如高血压、糖尿病,因此肾脏功能下降对心脏的直接作用一直不明确。

为探究这一问题,研究人员比较了68名肾脏捐赠者(平均年龄47岁)和56名对照者(平均年龄44岁)手术后第一年的情况。与对照组相比,研究人员发现,肾脏捐赠者出现了:肾功能预期的下降(使用肾小球滤过率和蛋白尿的出现评估肾功能);左心室质量的增加,这是心脏病风险的一个强有力的预测因子;心肌损伤标志物如肌钙蛋白增加;血压在两组无差异。

Townend 说:“该研究表明肾功能本身的减少将直接导致心脏和血管,造成可测量的不良影响,甚至在没有其他危险因素的条件下,该结论也成立。不过以后还需要更多的研究以了解肾功能的下降导致了哪些方面的直接影响。“

至于肾脏捐赠者,研究人员敦促他们不要担心新问题。Townend说:“只有健康的个体才能作为肾脏捐赠者,所以本研究在精确的测量下发现肾功能的下降以及心脏和血管的风险增加,但这些不利影响都是十分小的,就算捐赠者术后风险较前增加,但是也可能仍然低于平均风险。还有一点就是当前风险的改变是否会长期存在也仍不清楚。”

研究人员建议当发现肾功能下降时,医生应与患者交代心脏风险,同时早干预以降低风险。

原始出处:

Even small reductions in kidney function may damage heart, blood vessels.MedicalNewsToday.Jan 11,2016.


William E. Moody, Charles J. Ferro,et al.Cardiovascular Effects of Unilateral Nephrectomy in Living Kidney Donors.Hypertension.Jan 11,2016

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    2017-02-14 1ddf0692m34(暂无匿称)

    好文献

    0

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    2016-11-10 yese
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    2016-01-21 feather89
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