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BMC Surgery:食管切除术中羟乙基淀粉限制性液体治疗对术后疗效的影响

2019-03-18 不详 MedSci原创

为改善食管手术后患者的预后,术中液体优化非常重要。在此,研究人员探讨了在食管切除术中给予羟乙基淀粉来减少输注液体的总量,并探究其对术后并发症的发生和死亡率产生的影响。

背景
为改善食管手术后患者的预后,术中液体优化非常重要。在此,研究人员探讨了在食管切除术中给予羟乙基淀粉来减少输注液体的总量,并探究其对术后并发症的发生和死亡率产生的影响。

方法
研究人员对韩国所有接受过选择性食管癌手术的成年患者进行了研究。主要观察结果是复合并发症的发生(死亡,心脑血管并发症,呼吸系统并发症,肾脏并发症,肠道并发症,败血症,脓肿或脓肿,以及多器官衰竭)。同时使用多变量逻辑回归评估围手术期变量与复合并发症之间的关系。

结果
研究人员总共分析了892名患者,其中271名(30.4%)患者出现了复合并发症的发生。总液体中较高的羟乙基淀粉比率与总流体输注量呈负相关(r= -0.256,P<0.001)。在多变量分析中,术中给予每小时每小时总液体(比值比,1.248; 95%CI,1.153-1.351; P<0.001)和HES与晶体比率(优势比,2.125; 95%CI,1.521-2.969) ; P<0.001)与术后复合结果风险增加有关。

结论
尽管羟乙基淀粉给药减少了癌症食管手术期间的总输液量,但静脉注射羟乙基淀粉与术后复合并发症的风险增加有关。

原始出处:

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    2019-05-22 chg121
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topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 20 14:22:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478620, encodeId=74d114e8620cc, content=<a href='/topic/show?id=c2766588e36' target=_blank style='color:#2F92EE;'>#液体治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65887, encryptionId=c2766588e36, topicName=液体治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2397444617, createdName=1249859em40(暂无昵称), createdTime=Wed Mar 20 14:22:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032103, encodeId=b3ee1032103d7, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Tue Mar 19 02:22:00 CST 2019, time=2019-03-19, status=1, ipAttribution=)]
    2019-03-20 zhouqu_8
  8. 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  9. 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GetPortalCommentsPageByObjectIdResponse(id=1032103, encodeId=b3ee1032103d7, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Tue Mar 19 02:22:00 CST 2019, time=2019-03-19, status=1, ipAttribution=)]
    2019-03-19 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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