Baidu
map

精神心理科

订阅

MedSci主页 / 所有栏目 / 精神心理科

Brain Behav Immun：口腔致病菌感染与抑郁症的发生相关

2019-07-14 sunshine medsci

关注

横断面流行病学研究表明，牙周炎的发病率与抑郁症的发病率呈正相关。然而，二者之间因果关系和潜在机制尚未可知。牙龈卟啉单胞菌（Pg）是牙周炎的主要病原体。每隔一天使用Pg处理4周的雌性小鼠，结果发现Pg小鼠表现出明显的抑郁样行为，活化的星形胶质细胞数量增加，成熟脑源性神经营养因子（BDNF）和海马星形细胞p75NTR水平降低。海马注射BDNF和星形胶质细胞中p75NTR的过表达均减轻了Pg诱导的小鼠抑

横断面流行病学研究表明，牙周炎的发病率与抑郁症的发病率呈正相关。然而，二者之间因果关系和潜在机制尚未可知。

牙龈卟啉单胞菌（Pg）是牙周炎的主要病原体。每隔一天使用Pg处理4周的雌性小鼠，结果发现Pg小鼠表现出明显的抑郁样行为，活化的星形胶质细胞数量增加，成熟脑源性神经营养因子（BDNF）和海马星形细胞p75NTR水平降低。海马注射BDNF和星形胶质细胞中p75NTR的过表达均减轻了Pg诱导的小鼠抑郁样行为。此外，Pg-脂多糖（LPS）产生相似的表型，其被TLR-4抑制剂TAK242逆转。我们的结果表明Pg-LPS降低星形细胞p75NTR的水平，然后下调BDNF成熟，导致小鼠的抑郁样行为。

总之，该研究首次证明Pg是抑郁症可改变的危险因素，并揭示了治疗抑郁症的新治疗靶点。

原始出处：

Wang YX, Kang XN, et al.,  Porphyromonas gingivalis induces depression via downregulating p75NTR-mediated BDNF maturation in astrocytes. Brain Behav Immun. 2019 Jul 9. pii: S0889-1591(19)30304-6. doi: 10.1016/j.bbi.2019.07.012. 

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1947885, encodeId=7564194e88550, content=<a href='/topic/show?id=e54d8483db' target=_blank style='color:#2F92EE;'>#HAV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8483, encryptionId=e54d8483db, topicName=HAV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Oct 25 08:33:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521937, encodeId=19bf152193ed6, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626216, encodeId=72071626216a1, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369695, encodeId=ea753696953d, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Mon Jul 15 07:06:22 CST 2019, time=2019-07-15, status=1, ipAttribution=)]
    2019-10-25 12498cbcm00(暂无昵称)

    #HAV#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1947885, encodeId=7564194e88550, content=<a href='/topic/show?id=e54d8483db' target=_blank style='color:#2F92EE;'>#HAV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8483, encryptionId=e54d8483db, topicName=HAV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Oct 25 08:33:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521937, encodeId=19bf152193ed6, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626216, encodeId=72071626216a1, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369695, encodeId=ea753696953d, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Mon Jul 15 07:06:22 CST 2019, time=2019-07-15, status=1, ipAttribution=)]
    2019-07-16 qjddjq

    #EHA#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1947885, encodeId=7564194e88550, content=<a href='/topic/show?id=e54d8483db' target=_blank style='color:#2F92EE;'>#HAV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8483, encryptionId=e54d8483db, topicName=HAV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Oct 25 08:33:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521937, encodeId=19bf152193ed6, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626216, encodeId=72071626216a1, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369695, encodeId=ea753696953d, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Mon Jul 15 07:06:22 CST 2019, time=2019-07-15, status=1, ipAttribution=)]
    2019-07-16 cooco

    #致病菌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1947885, encodeId=7564194e88550, content=<a href='/topic/show?id=e54d8483db' target=_blank style='color:#2F92EE;'>#HAV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8483, encryptionId=e54d8483db, topicName=HAV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Oct 25 08:33:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521937, encodeId=19bf152193ed6, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626216, encodeId=72071626216a1, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Tue Jul 16 08:33:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369695, encodeId=ea753696953d, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Mon Jul 15 07:06:22 CST 2019, time=2019-07-15, status=1, ipAttribution=)]
    2019-07-15 百草

    666

    0

Baidu
map
Baidu
map
Baidu
map