Baidu
map

感染

订阅

MedSci主页 / 所有栏目 / 感染

MCP：肺结核治疗潜在的药物靶点

2017-06-08 MedSci MedSci原创

肺结核治疗
关注

肺结核是全球致死率最高的几种感染性疾病之一，每年有将近150万人死于肺结核感染。肺结核的主要致病菌是肺结核分枝杆菌（Mycobacterium tuberculosis, Mtb）。由于与HIV的共感染以及结核菌耐药问题的日益严重，结核病仍然是全球公共卫生领域的重大威胁。近日，国际杂志MCP在线发表了一遍关于肺结核治疗新靶点的研究。

肺结核是全球致死率最高的几种感染性疾病之一，每年有将近150万人死于肺结核感染。肺结核的主要致病菌是肺结核分枝杆菌（Mycobacterium tuberculosis, Mtb）。由于与HIV的共感染以及结核菌耐药问题的日益严重，结核病仍然是全球公共卫生领域的重大威胁。近日，国际杂志MCP在线发表了一遍关于前列腺癌转移机制的研究。

STPK在调控多种环境变化、细胞壁的合成、细胞分化以及病原-宿主相互作用中发挥了至关重要的作用。研究人员采用Mtb蛋白质组芯片进行了全部11种Mtb STPK相互作用蛋白质的系统性发现。他们构建了STPK蛋白相互作用网络，其中包含492种蛋白质以及1,027个相互作用。分析发现同细胞壁合成相关的蛋白被高度富集。进一步的功能研究表明，与细胞壁合成相关酶MurC可被PknG通过相互作用和磷酸化而进行调节。这些结果提示PknG与细胞壁的合成与调控密切相关，是一个潜在的药物靶点。

研究表明 STPK蛋白质相互作用网络为结核分枝杆菌的基础研究提供了一个很好的资源。解析蛋白质相互作用或将成为根本治疗肺结核的关键。

原始出处：

Hao M, Li Y, Wang J, Qin J, Wang Y, Ding Y. et.al. The Ser/Thr Protein Kinase Protein-Protein Interaction Map of M. tuberculosis. Mol Cell Proteomics. 2017 Jun 01;pii:M116.065771. doi:10.1074/mcp.M116.065771. [Epub ahead of print]

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1254076, encodeId=d5df12540e669, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384936, encodeId=f2b8138493685, content=<a href='/topic/show?id=93618e90631' target=_blank style='color:#2F92EE;'>#药物靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87906, encryptionId=93618e90631, topicName=药物靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208099, encodeId=eefa20809908, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208100, encodeId=d0502081009c, content=新思路，网状诊疗战略, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208098, encodeId=ded120809874, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jun 08 09:24:07 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-10 huhuaidong387

    #结核#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1254076, encodeId=d5df12540e669, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384936, encodeId=f2b8138493685, content=<a href='/topic/show?id=93618e90631' target=_blank style='color:#2F92EE;'>#药物靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87906, encryptionId=93618e90631, topicName=药物靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208099, encodeId=eefa20809908, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208100, encodeId=d0502081009c, content=新思路，网状诊疗战略, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208098, encodeId=ded120809874, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jun 08 09:24:07 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-10 xugc

    #药物靶点#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1254076, encodeId=d5df12540e669, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384936, encodeId=f2b8138493685, content=<a href='/topic/show?id=93618e90631' target=_blank style='color:#2F92EE;'>#药物靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87906, encryptionId=93618e90631, topicName=药物靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208099, encodeId=eefa20809908, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208100, encodeId=d0502081009c, content=新思路，网状诊疗战略, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208098, encodeId=ded120809874, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jun 08 09:24:07 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 中医痴

    不错的，学习了！谢谢分享！

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1254076, encodeId=d5df12540e669, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384936, encodeId=f2b8138493685, content=<a href='/topic/show?id=93618e90631' target=_blank style='color:#2F92EE;'>#药物靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87906, encryptionId=93618e90631, topicName=药物靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208099, encodeId=eefa20809908, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208100, encodeId=d0502081009c, content=新思路，网状诊疗战略, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208098, encodeId=ded120809874, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jun 08 09:24:07 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 lyh994

    新思路，网状诊疗战略

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1254076, encodeId=d5df12540e669, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384936, encodeId=f2b8138493685, content=<a href='/topic/show?id=93618e90631' target=_blank style='color:#2F92EE;'>#药物靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87906, encryptionId=93618e90631, topicName=药物靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Sat Jun 10 00:20:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208099, encodeId=eefa20809908, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208100, encodeId=d0502081009c, content=新思路，网状诊疗战略, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Thu Jun 08 09:26:59 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208098, encodeId=ded120809874, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jun 08 09:24:07 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 Jackie Li

    学习

    0

相关资讯

NEJM：偶然发现的油胸 -案例报道

考虑到该患者的肺结核治疗史，最可能的诊断是油胸-肺结核的一种治疗方式，已经废弃了多年，涉及将油灌注进入胸膜腔使肺塌陷。通常情况下，治疗后，油被吸收的过程可以持续长达2年。然而，无症状的患者有时会失访，并且油留在原位，正如在这个病人身上发生的一样。长期并发症，包括重叠感染和气道阻塞，也有报导。这个病人没有出现并发症或油胸相关症状

Science：利用小分子SMARt-420逆转结核分枝杆菌的抗生素耐药性

在一项新的研究中，来自瑞典、法国、比利时和瑞士的一个研究团队发现一种方法逆转对一种用于治疗肺结核的抗生素药物产生的耐药性。在他们发表在2017年3月17日的Science期刊上的论文中，该团队描述了他们如何筛选激活用于活化ethionaide的不同通路的化合物。Ethionaide是一种被用来治疗肺结核的前体分子，在体内经过代谢后产生一种真正有

世界防治结核病日 盘点近年来结核病研究领域的亮点成果

今年3月24日是第22个世界防治结核病日，今年的结核病日的宣传主题是“社会共同努力，消除结核危害”。2016年，世卫组织报告全球1040万人患结核病，2015年有180万因结核病死亡，如今结核病已经成为世界上最大的传染病杀手，这种疾病深深植根于人权和尊严受限的人群中。 近些年来，科学家们在结核病研究领域取得了很多突破性的进展，本文中小编就对此进行了整理，与各位一起共同学习！

Nature子刊：科学家有望开发出治疗肺结核的靶向性药物

图片来源：www.phys.org 近日，一项刊登在国际杂志Nature Chemical Biology上的研究报告中，来自普渡大学的研究人员通过研究发现了拦截机体免疫系统对肺结核产生反应的机制，这或许就为科学家们提供了一种新型药物靶点来帮助开发治疗肺结核的新型药物。文章中研究者阐明了结核分枝杆菌如何关闭人类细胞对细菌产生的免疫反应。 肺结核是一种因感染结核分枝杆菌而引发的传染性疾病，该

Nat Commun：土壤细菌衍生的特殊化合物或有望成为抵御肺结核的新型疗法

日前，一项刊登在国际杂志Nature Communications上的研究报告中，来自英国华威大学等多个机构的研究人员通过研究利用来自土壤中细菌衍生的化合物开发出了治疗肺结核（TB）的新型疗法。 文章中，研究者发现，某种土壤细菌所产生的化合物能够有效抑制其周围的细菌生长，利用合成化学技术，研究

Lancet Infect Dis：耐药性肺结核的流行趋势

印度、菲律宾、俄罗斯和南非4个国家的多药耐药以及扩大耐药型肺结核比例将达到较高水平，加强药物抵抗预防将有助于减缓耐药性肺结核在全球的流行趋势

Baidu
map
Baidu
map
Baidu
map