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Gastroenterology:预防慢性乙肝患者肝癌的治疗方法

2014-07-01 佚名 不详

乙型肝炎一种最严重的并发症之一是肝癌。发表在Gastroenterology杂志上的两个新的研究提供了有力的证据表明:抗病毒治疗可减少慢性乙肝感染患者肝癌的风险。 在一篇论文中,台湾国立阳明大学研究人员表明,使用批准的口服抗病毒药物核苷(酸)(NUC)降低慢性乙型肝炎患者肝癌长期风险。这项回顾性研究分析了几个不同药物治疗患者的肝细胞癌(肝癌的最常见形式)的风险。与对照组相比,NUC处理患者肝癌发

乙型肝炎一种最严重的并发症之一是肝癌。发表在Gastroenterology杂志上的两个新的研究提供了有力的证据表明:抗病毒治疗可减少慢性乙肝感染患者肝癌的风险。

在一篇论文中,台湾国立阳明大学研究人员表明,使用批准的口服抗病毒药物核苷(酸)(NUC)降低慢性乙型肝炎患者肝癌长期风险。这项回顾性研究分析了几个不同药物治疗患者的肝细胞癌(肝癌的最常见形式)的风险。与对照组相比,NUC处理患者肝癌发病率显著低。总体而言,NUC治疗能降低癌症的风险,其在无肝硬化年轻患者中和非糖尿病患者中效果最明显。主要作者Chun-Ying Wu博士说:研究结果表明,使用NUC降低慢性乙型肝炎患者的肝癌风险,尤其是在最小肝损害的年轻患者中。

第二项回顾性分析研究中,比较韩国首尔某三级医院的慢性乙型肝炎患者接受抗病毒药物恩替卡韦治疗和不太有效的药物拉米夫定治疗的结果。研究人员发现,与用拉米夫定治疗的患者相比,恩替卡韦组患者死亡或移植风险显著较低,然而,死亡或移植风险降低并没有转化为肝癌风险降低,两组均肝癌风险有着相似的降低。即使是最有效的药物治疗,乙肝患者也有患肝癌的持续风险。根据研究发现表明,慢性乙肝患者无论使用何种治疗,肝癌都应继续被监察。

原始出处

Wu CY1, Lin JT2, Ho HJ3, Su CW4, Lee TY5, Wang SY6, Wu C6, Wu JC7.Association of Nucleos(t)ide Analogue Therapy With Reduced Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B-A Nationwide Cohort Study.Gastroenterology. 2014 Jul;

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    2015-04-26 许安
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    2014-08-26 kukuwawawa

    额,这是肯定的啦

    0

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