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Neuroendocrinology:采用保脾远端胰腺切除术(SPDP)治疗胰腺神经内分泌肿瘤的长期预后

2020-02-13 QQY MedSci原创

背景:采用保脾远端胰腺切除术(SPDP)治疗胰腺神经内分泌肿瘤(pNETs)等恶性疾病一直存在争议。本研究旨在评估SPDP对pNETs患者预后的影响。方法:纳入2002年-2016年在美国接受远端胰切除术(DP)的患者。采用倾向得分匹配方法 (PSM)对比采用SPDP或胰远端联合脾切除术(DPS)治疗的患者的短期和长期预后。结果:共纳入了621位患者,其中103位(16.6%)采用SPDP治疗。采

背景:采用保脾远端胰腺切除术(SPDP)治疗胰腺神经内分泌肿瘤(pNETs)等恶性疾病一直存在争议。本研究旨在评估SPDP对pNETs患者预后的影响。

方法:纳入2002年-2016年在美国接受远端胰切除术(DP)的患者。采用倾向得分匹配方法 (PSM)对比采用SPDP或胰远端联合脾切除术(DPS)治疗的患者的短期和长期预后。

结果:共纳入了621位患者,其中103位(16.6%)采用SPDP治疗。采用SPDP治疗的患者的BMI往往更低(中位值 27.5[IQR 24.0-31.2] vs 28.7[IQR 25.7-33.6];p=0.005),并多接受过微创手术(56例[54.4%] vs 185例[35.7%]; p<0.001)。PSM后,SPDP术后患者的淋巴结检查中位总数低于DPS术后的患者的(3 vs 9;p<0.001),两种手术治疗的患者的5年总存活率和无复发存活率相当。此外,与DPS治疗的患者相比,经SPDP治疗的患者术中失血更少(100ml vs 150ml;p<0.001),重度并发症发生率更低(12.8% vs 27.5%;p=0.014),住院时间更短(5天 vs 6天;p=0.049)。

结论:采用SPDP治疗pNET的围手术区和长期预后与采用DPS治疗的相当。应考虑采用SPDP治疗pNET。

原始出处:

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createdName=jiafufeng@yaho, createdTime=Sat Feb 15 13:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
  5. 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createdName=jiafufeng@yaho, createdTime=Sat Feb 15 13:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1785217, encodeId=04aa1e85217f0, content=<a href='/topic/show?id=4c2a6e614a' target=_blank style='color:#2F92EE;'>#Endocrinology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6761, encryptionId=4c2a6e614a, topicName=Endocrinology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Sat Dec 19 22:09:00 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877252, encodeId=78e818e7252c5, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, 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createdName=jiafufeng@yaho, createdTime=Sat Feb 15 13:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83947, encryptionId=8c338394e02, topicName=胰腺切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Jul 03 22:09:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682591, encodeId=c87316825919d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue Dec 15 22:09:00 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763510, encodeId=55461e6351068, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Mon Mar 16 20:09:00 CST 2020, time=2020-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553013, encodeId=f50c15530130b, content=<a href='/topic/show?id=a46c839869c' target=_blank style='color:#2F92EE;'>#胰腺神经内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83986, encryptionId=a46c839869c, topicName=胰腺神经内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99714344271, createdName=jiafufeng@yaho, createdTime=Sat Feb 15 13:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
    2020-12-15 gwc392
  8. 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createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Dec 07 10:09:00 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809851, encodeId=57bb18098517e, content=<a href='/topic/show?id=71bb8394690' target=_blank style='color:#2F92EE;'>#胰腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83946, encryptionId=71bb8394690, topicName=胰腺切除)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Tue Aug 18 10:09:00 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645623, encodeId=68e61645623a6, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Sun Mar 01 20:09:00 CST 2020, time=2020-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953763, encodeId=df3a1953e63bd, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Sat Mar 21 13:09:00 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069956, encodeId=8552206995681, content=<a href='/topic/show?id=8c338394e02' target=_blank style='color:#2F92EE;'>#胰腺切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83947, encryptionId=8c338394e02, topicName=胰腺切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Jul 03 22:09:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682591, encodeId=c87316825919d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue Dec 15 22:09:00 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763510, encodeId=55461e6351068, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Mon Mar 16 20:09:00 CST 2020, time=2020-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553013, encodeId=f50c15530130b, content=<a href='/topic/show?id=a46c839869c' target=_blank style='color:#2F92EE;'>#胰腺神经内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83986, encryptionId=a46c839869c, topicName=胰腺神经内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99714344271, createdName=jiafufeng@yaho, createdTime=Sat Feb 15 13:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1785217, encodeId=04aa1e85217f0, content=<a href='/topic/show?id=4c2a6e614a' target=_blank style='color:#2F92EE;'>#Endocrinology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6761, encryptionId=4c2a6e614a, topicName=Endocrinology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Sat Dec 19 22:09:00 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877252, encodeId=78e818e7252c5, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Dec 07 10:09:00 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809851, encodeId=57bb18098517e, content=<a href='/topic/show?id=71bb8394690' target=_blank style='color:#2F92EE;'>#胰腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83946, encryptionId=71bb8394690, topicName=胰腺切除)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Tue Aug 18 10:09:00 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645623, encodeId=68e61645623a6, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83947, encryptionId=8c338394e02, topicName=胰腺切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Jul 03 22:09:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682591, encodeId=c87316825919d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue Dec 15 22:09:00 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763510, encodeId=55461e6351068, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Mon Mar 16 20:09:00 CST 2020, time=2020-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553013, encodeId=f50c15530130b, content=<a href='/topic/show?id=a46c839869c' target=_blank style='color:#2F92EE;'>#胰腺神经内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83986, encryptionId=a46c839869c, topicName=胰腺神经内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99714344271, createdName=jiafufeng@yaho, createdTime=Sat Feb 15 13:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
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