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Diabetes Obes Metab:1型糖尿病和肥胖患者强化的多学科体重管理疗效分析

2018-08-01 xing.T MedSci原创

由此可见,与标准治疗相比,参加IMWM计划的T1D和肥胖患者在一年时体重明显减轻,并且每日胰岛素剂量显著减少。与基线相比,体重减轻与血糖控制的改善相关。

最近的研究报道大约50%的1型糖尿病(T1D)患者存在超重或肥胖。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,该研究旨在探究强化的多学科体重管理(IMWM)对T1D和肥胖患者的疗效。

研究人员回顾性地评估了68例T1D和肥胖患者,这些患者参加了为期12周的IMWM计划(IMWM队列:平均年龄为42±11岁,HbA1c为8.3±1.0%,体重为104.3±18.2kg,BMI为36.2±4.9kg/m2)。研究人员将以1:1比例匹配接受标准治疗的类似队列(SC队列:平均年龄为42±12岁,HbA1c为8.3±1.0%,体重为102.4±17.9kg,BMI为36.1±4.7kg/m2)。研究人员收集了受试者基线和12个月的数据。

IMWM队列的参与者体重变化为较初始体重降低了6.6±1.8kg或6.4±1.6%,而SC队列没有变化(组别与时间相互作用p<0.01)。IMWM队列的HbA1c变化较基线降低了0.4±0.1%(p<0.01),而SC队列没有变化。在干预12个月时,组间的血糖控制没有差异。IMWM队列每日总胰岛素剂量较基线降低了5.9±1.8个单位/天,而SC组没有变化(组别与时间相互作用p<0.01)。

由此可见,与标准治疗相比,参加IMWM计划的T1D和肥胖患者在一年时体重明显减轻,并且每日胰岛素剂量显著减少。与基线相比,体重减轻与血糖控制的改善相关。

原始出处:

Adham Mottalib,et al. Intensive Multidisciplinary Weight Management in Patients with Type 1 Diabetes and Obesity: a 1‐Year Retrospective Matched Cohort Study.Diabetes Obesity & Metabolism.2018. https://doi.org/10.1111/dom.13478

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CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439936, encodeId=f80e14399362d, content=<a href='/topic/show?id=35904318480' target=_blank style='color:#2F92EE;'>#多学科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43184, encryptionId=35904318480, topicName=多学科)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 03 00:39:00 CST 2018, time=2018-08-03, status=1, ipAttribution=)]
    2019-02-28 guojianrong
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1型糖尿病(T1D),原名胰岛素依赖型糖尿病,起病比较急剧,患者体内胰岛素绝对不足,容易发生酮症酸中毒,必须用胰岛素治疗才能获得满意疗效,否则将危及生命。但是,由于怕疼、恐针等原因,许多患者未能每日一次或两次按时注射,对健康造成严重影响,而口服胰岛素由于药物利用率等问题未曾问世,因此,科学家们试图找寻可协助胰岛素治疗糖尿病的途径。近日,《Nature Medicine》发表的一篇文章提出高血压常用

Boehringer Ingelheim和Lilly宣布empagliflozin作为1型糖尿病胰岛素的辅助治疗的全新结果

勃林格殷格翰公司和礼来公司今天宣布EAS​​E III期随机对照试验的研究结果显示,empagliflozin联合胰岛素治疗在成人1型糖尿病中的应用符合主要终点。所有研究剂量的empagliflozin(2.5、10和25 mg)均符合主要疗效终点。

Diabetic Med:在使用胰岛素泵治疗的1型糖尿病患者中以碳水化合物为主的低血糖治疗的效果如何?

近日,国际杂志 《Diabetic Med》上在线发表一项关于基于体重的碳水化合物治疗的随机交叉临床试验的研究。为了测试接受持续皮下胰岛素输注治疗的1型糖尿病患者,基于体重治疗低血糖和避免过度反弹性高血糖是否比常规治疗更有效。 连续皮下注射胰岛素的儿童和成人参加了交叉设计的研究。低血糖发作患者(定义为毛细血管葡萄糖<4.0mmol/l)被随机分配到使用葡萄糖片的两种治疗方案中的一种:0

2018 ISPAD临床实践共识指南:儿童和青少年1型糖尿病的分期

2018年7月,国际儿童青少年糖尿病协会(ISPAD)发布了儿童和青少年1型糖尿病的分期共识指南,指南主要更新点如下:糖尿病新的分类改为为1-3阶段,预测1型糖尿病的工具包括遗传风险评分,更新了干预试验信息,包括一级预防和1和2阶段糖尿病。

Diabetic Med:连续血糖监测和闪速血糖监测对1型糖尿病患者的影响

近日,国际杂志 《Diabetic Med》上在线发表一项关于1型糖尿病患者连续血糖监测和闪速血糖监测的随机对照试验以及低血糖意识障碍的研究。 1型糖尿病的低血糖与死亡率和发病率有关,特别是在低血糖意识受损的情况下。获得连续血糖监测(CGM)和闪速血糖监测技术的临床途径尚不清楚。研究人员评估了CGM和快速血糖监测对1型糖尿病高危人群的影响。 研究人员进行随机、非盲平行组研究。使用多次

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