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JAMA Psychiatry:儿童期持续的行为性睡眠问题导致青春期精神疾病风险增加

2020-07-07 MedSci原创 MedSci原创

儿童期的一些行为性睡眠问题与青少年期精神病和边缘型人格障碍风险显著相关。

儿童期持续的行为性睡眠问题(如噩梦)与青春期精神病和边缘型人格障碍(BPD)风险有关,但行为性睡眠问题在其中的重要性,及其潜在的机制研究尚不充分。
 
近日研究招募父母报告的儿童早期睡眠问题患儿,考察睡眠问题与11-13岁的精神病性症状和BPD症状之间的潜在联系。本次研究随访时间超过13年,总计包含13488名参与者。采用精神病样症状访谈法对12至13岁患儿的精神病经历进行评估,并采用英国儿童访谈法对11至12岁的患儿BPD症状进行DSM-IV边缘人格障碍测试。在孩子6、18和30个月以及3.5、4.8和5.8岁时进行父母报告的夜间睡眠时间、夜间觉醒频率、就寝时间和睡眠常规规律评估。
 
研究发现,18个月大时夜间觉醒频率较高(优势比[OR]:1.13),6个月(OR:0.68)、30个月(OR:0.64)和5.8岁(OR:0.32)时睡眠规律异常与青少年的精神病风险显著相关,而较短的夜间睡眠时间(OR:0.78、)和3.5岁的晚睡时间(OR:1.32)与BPD症状显著相关。除了3.5岁的晚睡和青春期的BPD相关性之外,调整后其他结果保持一致。10岁时的抑郁症症状与18个月大时频繁夜间醒来(偏差校正估计值-0.005,P=0.002)和5.8岁时不规律的睡眠习惯(偏差校正估计值-0.006)相关。
 
研究结果表明,儿童期的一些行为性睡眠问题与青少年期精神病和边缘型人格障碍风险显著相关。
 
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    2020-07-07 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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