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Diabetic Med:在临床实践中被低估的非酒精性脂肪性肝病的患病率和严重程度

2018-03-25 MedSci MedSci原创

为了明确糖尿病专家对非酒精性脂肪性肝病的观点和目前的临床实践,并根据研究结果,实施非酒精性脂肪性肝病评估的循证途径。近日,国际杂志 《Diabetic Med》上在线发表一项关于非酒精性脂肪性肝病的患病率和严重程度在临床实践中被低估的专用筛查方法的影响的研究。 研究首先将网上调查分发给糖尿病专家,然后根据这次调查的结果,研究人员发起一个意识活动,并在所有糖尿病诊所在二级/三级转诊中心实施筛

为了明确糖尿病专家对非酒精性脂肪性肝病的观点和目前的临床实践,并根据研究结果,实施非酒精性脂肪性肝病评估的循证途径。近日,国际杂志 《Diabetic Med》上在线发表一项关于非酒精性脂肪性肝病的患病率和严重程度在临床实践中被低估的专用筛查方法的影响的研究。

研究首先将网上调查分发给糖尿病专家,然后根据这次调查的结果,研究人员发起一个意识活动,并在所有糖尿病诊所在二级/三级转诊中心实施筛查算法。

共有133名糖尿病专家对这项调查进行了回应。不到5%的应答者正确评估糖尿病患者晚期纤维化非酒精性脂肪肝疾病的患病率和严重程度。虽然大多数临床医生进行肝功能检查,但只有5.7%的人会使用或使用非侵入性算法来评估非酒精性脂肪肝的严重程度。研究人员采用预先印制的血液检查表格实施局部非酒精性脂肪肝疾病意识活动和筛查策略,并确保100%(n=395)所有12型糖尿病患者在6个月内接受二级/三级保健糖尿病诊所的筛查,使用Fib-4指数对晚期纤维化非酒精性脂肪性肝病进行适当的筛查;17.9%需要进一步调查或评估。

研究表明,糖尿病专家低估了非酒精性脂肪肝的发病率和严重程度。Fib-4指数可以很容易地纳入二级/三级医疗的临床实践中,以确定那些有进展性纤维化风险的人需要进一步评估,并且可以从专业的多学科方法中受益。

原始出处:

T. Marjot, E. Sbardella, A. Moolla,et al. Prevalence and severity of non-alcoholic fatty liver disease are underestimated in clinical practice: impact of a dedicated screening approach at a large university teaching hospital

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objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Sun Oct 28 01:09:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760597, encodeId=75751e6059736, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Feb 14 04:09:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250529, 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07:09:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608682, encodeId=90e8160868222, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Mar 27 07:09:00 CST 2018, time=2018-03-27, status=1, ipAttribution=)]
    2019-01-10 qjddjq
  5. [GetPortalCommentsPageByObjectIdResponse(id=1638508, encodeId=77d91638508bf, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Sep 09 06:09:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673382, encodeId=70a716e338266, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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07:09:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608682, encodeId=90e8160868222, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Mar 27 07:09:00 CST 2018, time=2018-03-27, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1638508, encodeId=77d91638508bf, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Sep 09 06:09:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673382, encodeId=70a716e338266, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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2型糖尿病的降糖干预显示微血管并发症减少,大血管并发症适度降低。然而,针对不同HbA 1c降低的程度可能降低风险尚不清楚。近日,国际杂志 《Diabetic Med》上在线发表一项关于以降低2型糖尿病和心血管疾病患者的HbA 1c水平为目标,对并发症发生率进行建模。 使用西格列汀(TECOS)心血管疾病参与者的评估心血管结局的参与者水平数据使用在2型糖尿病特异性模拟模型中,用于量化不同HbA

这例胸痛的罪魁祸首竟是……

患者,男性,18岁,因“胸痛、呼吸急促5小时”就诊。该患者入院5小时前无明显诱因下出现胸痛,胸痛部位以胸骨下段为主,呈持续性,较剧烈,无放射性感觉,伴明显呼吸急促,深呼吸及进食动作后明显,该患者无畏寒发热,无咳嗽咳痰咯血呼吸困难,无腹痛腹泻、恶心呕吐等伴随症状。

上海生科院等揭示代谢性手术治疗糖尿病的转归路径

近日,中国科学院上海生命科学研究院生物化学与细胞生物学研究所系统生物学重点实验室吴家睿、曾嵘、陈洛南研究组,与丹麦哥本哈根大学 Jens J. Holst 研究组合作的研究论文,以 Systems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery 为题,发表在 EBioMe

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