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Ann Surg:肌肉减少症与食管癌术后的关系如何

2017-04-25 MedSci MedSci原创

目前,有研究认为,随着年龄增长而出现的骨骼肌减少症是恶性肿瘤的不良预后因素。近期,一项发表在杂志Ann Surg上的研究旨在阐明肌营养不良对老年食管癌患者术后并发症和食管癌术后长期存活的影响。此项研究回顾性分析调查了少肌症对年轻和老年食管癌患者手术结局的影响。研究者们收集了341例接受食管癌食管切除术的患者资料。根据年龄以及存在肌肉减少症将患者分为2组(65岁以下,65岁及以上)。此项研究结果显示

目前,有研究认为,随着年龄增长而出现的骨骼肌减少症是恶性肿瘤的不良预后因素。


近期,一项发表在杂志Ann Surg上的研究旨在阐明肌营养不良对老年食管癌患者术后并发症和食管癌术后长期存活的影响。

此项研究回顾性分析调查了少肌症对年轻和老年食管癌患者手术结局的影响。研究者们收集了341例接受食管癌食管切除术的患者资料。根据年龄以及存在肌肉减少症将患者分为2组(65岁以下,65岁及以上)。

此项研究结果显示:在341例食管癌患者中有170例(49.9%)存在少肌症,166例老年患者中有74例(44.6%)存在。老年肌肉减少组患者的吻合口瘘和住院死亡发生率明显高于老年非肌肉减少组患者(31.5%vs 15.2%,P = 0.015;6.8 vs 0.0%,P = 0.037);老年组中,少肌症患者的生存率与预后较差相关(P <0.001)。多变量分析显示,肌肉减少症是吻合口瘘的危险因素(P = 0.034),是不利于生存的预后因素(P <0.001)。在年轻患者组中没有观察到肌肉减少症和手术结局之间的相关性。

此项研究表明:在65岁及以上的食管癌患者中,少肌症和较差的手术结果显着相关,但65岁以下的患者中,两者关系不显着。

原始出处:
Nakashima Y, Saeki H, et al. Assessment of Sarcopenia as a Predictor of Poor Outcomes After Esophagectomy in Elderly Patients With Esophageal Cancer. Ann Surg. 2017 Apr 21. doi: 10.1097/SLA.0000000000002252.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1647080, encodeId=bed7164e08055, content=<a href='/topic/show?id=fd6d809e535' target=_blank style='color:#2F92EE;'>#肌肉减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80975, encryptionId=fd6d809e535, topicName=肌肉减少)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18723374958, createdName=shizhenshan, createdTime=Sun Mar 11 03:17:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219038, encodeId=74cc2190385f, content=学习了。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Thu Jul 06 07:22:23 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211704, encodeId=98d6211e04bd, content=学习了,谢谢~非常新颖的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicUw7yoAI4gptl6B3VGw6WZJ0uC02gdsRKGWuUVO3YSn6iagP9laH8FZIo3kTr5Xb9ricn6kqveJVs6FOWPec9yClJFkTXHtxSA/0, createdBy=a44f1685526, createdName=drdentist, createdTime=Sat Jun 17 00:19:14 CST 2017, time=2017-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191571, encodeId=06631915e177, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eotHc7cjrVcIHD9L2n3LzcQo1WSYledtExBOM76QRXV0FrtWOsoLNA9xaJmBjsBFwPvC7fNarGfAg/132, createdBy=531e1939570, createdName=一个尘埃, createdTime=Fri Apr 28 21:16:03 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393377, encodeId=ca0a13933e708, content=<a href='/topic/show?id=e2f4809e7e9' target=_blank style='color:#2F92EE;'>#肌肉减少症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80977, encryptionId=e2f4809e7e9, topicName=肌肉减少症)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Thu Apr 27 11:17:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437192, encodeId=2694143e1923f, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Apr 27 11:17:00 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-07-06 hfuym10906

    学习了。。。。。。。

    0

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    2017-06-17 drdentist

    学习了,谢谢~非常新颖的研究

    0

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    2017-04-28 一个尘埃

    学习了,谢谢分享。

    0

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    2017-04-27 zhouqu_8

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