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JCEM：PET-CT扫描可诊断可治愈Conn症

2011-12-12 MedSci原创 MedSci原创

PET-CT诊断
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英国剑桥大学等机构的研究人员在新一期美国《临床内分泌学与新陈代谢杂志》（The Journal of Clinical Endocrinology and Metabolism）上报告说，可以使用PET-CT扫描来诊断康氏症。 高血压是困扰很多人的顽症，但由某些疾病引发的高血压其实是可以治愈的，比如由康氏症引发的高血压，但医生面临的一个难题是如何快捷地断定某人所患的高血压确由康氏症引起。

英国剑桥大学等机构的研究人员在新一期美国《临床内分泌学与新陈代谢杂志》（The Journal of Clinical Endocrinology and Metabolism）上报告说，可以使用PET-CT扫描来诊断康氏症。

高血压是困扰很多人的顽症，但由某些疾病引发的高血压其实是可以治愈的，比如由康氏症引发的高血压，但医生面临的一个难题是如何快捷地断定某人所患的高血压确由康氏症引起。

康氏症又名原发性醛类脂醇过多症，可由肾上腺部位肿瘤引起，它会导致与血压有关的激素分泌失调，从而引发高血压。但只要摘除肿瘤，就可以把这种高血压治愈。然而引发高血压的原因很多，过去只有通过微创手术获得肾上腺部位的血液样本，对血样进行分析后才能确定是康氏症，这种方法费时费力。

研究人员开发出一种特殊的放射性指示剂，它能在扫描时以高亮度影像显示出肾上腺部位的肿瘤。这种扫描和显影所需时间不到一小时，尔后就能在计算机辅助下判断某患者的高血压病因是否为康氏症。

领导该研究的莫里斯·布朗说，他和同事对几十名患者开展的临床试验显示，这种方法准确度高，与传统的微创手术方法相比减少了很多麻烦，得到检测结果的时间更快，因此该方法在相关诊断中有望成为替代微创检测的有效方法。（生物谷Bioon.com）

doi:10.1210/jc.2011-1537

Evaluation of the Sensitivity and Specificity of 11C-Metomidate Positron Emission Tomography (PET)-CT for Lateralizing Aldosterone Secretion by Conn's Adenomas

Timothy J. Burton, Isla S. Mackenzie, Kottekkattu Balan, Brendan Koo, Nick Bird, Dmitri V. Soloviev, Elena A. B. Azizan, Franklin Aigbirhio, Mark Gurnell and Morris J. Brown

Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). 11C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.The objective of the study was to compare the sensitivity and specificity of 11C-metomidate PET-computed tomography (CT) against the current gold standard of AVS.The design of the study was within-patient comparison of diagnostic techniques.The study was conducted at a single center-university teaching hospital.11C-metomidate PET-CT is a sensitive and specific noninvasive alternative to AVS in the management of PHA.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1777373, encodeId=fc081e7737372, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed May 16 07:00:00 CST 2012, time=2012-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062746, encodeId=a3b52062e46a4, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Jul 04 23:00:00 CST 2012, time=2012-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725400, encodeId=9feb1e254003e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Nov 09 09:00:00 CST 2012, time=2012-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331005, encodeId=3c36133100565, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Wed Dec 14 14:00:00 CST 2011, time=2011-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426254, encodeId=e9601426254d8, content=<a href='/topic/show?id=a4ef140e620' target=_blank style='color:#2F92EE;'>#PET-CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14076, encryptionId=a4ef140e620, topicName=PET-CT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21cd4047192, createdName=saikp, createdTime=Wed Dec 14 14:00:00 CST 2011, time=2011-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618750, encodeId=fc8b1618e50bf, content=<a href='/topic/show?id=aa2e5463db' target=_blank style='color:#2F92EE;'>#CT扫描#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5463, encryptionId=aa2e5463db, topicName=CT扫描)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed3819951332, createdName=ms6323715314570549, createdTime=Wed Dec 14 14:00:00 CST 2011, time=2011-12-14, status=1, ipAttribution=)]
    2012-05-16 smallant2015

    #JCEM#

    0

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    2012-07-04 achengzhao

    #JCE#

    0

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    2012-11-09 feather89

    #PE#

    0

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    2011-12-14 ms7514935887898259

    #PET#

    0

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    2011-12-14 saikp

    #PET-CT#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777373, encodeId=fc081e7737372, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed May 16 07:00:00 CST 2012, time=2012-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062746, encodeId=a3b52062e46a4, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Jul 04 23:00:00 CST 2012, time=2012-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725400, encodeId=9feb1e254003e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Nov 09 09:00:00 CST 2012, time=2012-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331005, encodeId=3c36133100565, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Wed Dec 14 14:00:00 CST 2011, time=2011-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426254, encodeId=e9601426254d8, content=<a href='/topic/show?id=a4ef140e620' target=_blank style='color:#2F92EE;'>#PET-CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14076, encryptionId=a4ef140e620, topicName=PET-CT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21cd4047192, createdName=saikp, createdTime=Wed Dec 14 14:00:00 CST 2011, time=2011-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618750, encodeId=fc8b1618e50bf, content=<a href='/topic/show?id=aa2e5463db' target=_blank style='color:#2F92EE;'>#CT扫描#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5463, encryptionId=aa2e5463db, topicName=CT扫描)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed3819951332, createdName=ms6323715314570549, createdTime=Wed Dec 14 14:00:00 CST 2011, time=2011-12-14, status=1, ipAttribution=)]
    2011-12-14 ms6323715314570549

    #CT扫描#

    0

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