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Acta Radiol: 前列腺肿瘤放射治疗后的监测研究

2018-09-26 AlexYang MedSci原创

放射治疗后效果的纵向监测可以通过动态超声造影成像(DCE-US)来实现。最近,有研究人员利用DCE-US在一个人类前列腺癌小鼠皮下模型中评估了相关的功能性参数,并且探究了治疗后剂量累计和时间时限的相关性。另外,研究人员还特别关注且评估了肿瘤的血管异质性,并利用了最合适的数据分析方法来反应上述异质性。研究人员在 7.5 Gy和10 Gy单独剂量放射治疗后的24小时和48小时时分别获得了DCE-US数

放射治疗后效果的纵向监测可以通过动态超声造影成像(DCE-US)来实现。最近,有研究人员利用DCE-US在一个人类前列腺癌小鼠皮下模型中评估了相关的功能性参数,并且探究了治疗后剂量累计和时间时限的相关性。另外,研究人员还特别关注且评估了肿瘤的血管异质性,并利用了最合适的数据分析方法来反应上述异质性。

研究人员在 7.5 Gy和10 Gy单独剂量放射治疗后的24小时和48小时时分别获得了DCE-US数据。研究发现,在放射治疗24小时和48小时时检测到了显著的纵向变化(P<0.001)。在48小时时,治疗组造影剂的消除速率常数与微血管密度 (MVD; rτ=0.7) 呈现正相关关系(P  ≤ 0.05),并且与坏死(rτ=-0.6)呈现负相关关系。更进一步的是,Akep,一个与经毛细血管传输特性恶性相关的参数,与MVD也相关(rτ=0.6, P ≤ 0.05)。

最后,研究人员指出,DCE-US能够在放射治疗后的早期阶段检测血管变化,这是一个非常大的优势,并且DCE-US没有侵入性,在大多医院均可以使用。另外,与临床实践其他技术相比花费较低。

原始出处:

Arteaga-Marrero N, Mainou-Gomez JF, Brekke Rygh C et al. Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts. Acta Radiol. Sep 19 2018.

本文系梅斯医学(MedSci)原创编译和整理,转载需授权!

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    2019-09-05 windight
  3. [GetPortalCommentsPageByObjectIdResponse(id=1771469, encodeId=d6bb1e71469ca, content=<a href='/topic/show?id=3e0432563e5' target=_blank style='color:#2F92EE;'>#前列腺肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32563, encryptionId=3e0432563e5, topicName=前列腺肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=257238300920, createdName=gous, createdTime=Thu Sep 27 06:36:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849617, encodeId=b571184961e19, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Thu Sep 05 22:36:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018053, encodeId=e54420180538c, content=<a href='/topic/show?id=8fba8295380' target=_blank style='color:#2F92EE;'>#肿瘤放射治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82953, encryptionId=8fba8295380, topicName=肿瘤放射治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Mon Aug 19 23:36:00 CST 2019, time=2019-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346938, encodeId=f7a53469381d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Sep 27 18:31:45 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346740, encodeId=cbc7346e40f7, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 26 12:47:20 CST 2018, time=2018-09-26, status=1, ipAttribution=)]
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    2018-09-27 一个字-牛

    学习了谢谢分享

    0

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    2018-09-26 惠映实验室

    学习了,谢谢分享。

    0

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