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Clinical Gastroenterology H: 慢性炎症性肠病活动的Nancy指数评分与大肠肿瘤发病相关

2019-12-27 不详 MedSci原创

组织学和内镜下疾病活动的程度与炎性肠病(IBDs)患者大肠肿瘤形成(CRN)的风险增加相关,但是尚无任何组织学评分系统可用于确定CRN的风险。本项研究调查了存在组织学和内镜下疾病活动的IBD患者与CRN风险之间的关联。

背景与目标
组织学和内镜下疾病活动的程度与炎性肠病(IBDs)患者大肠肿瘤形成(CRN)的风险增加相关,但是尚无任何组织学评分系统可用于确定CRN的风险。本项研究调查了存在组织学和内镜下疾病活动的IBD患者与CRN风险之间的关联。

方法
研究人员对从1996年1月1日至2015年3月1日在法国圣安东尼医院接受至少2例结肠镜检查的患者进行了回顾性分析。IBD组织学疾病活性通过南希组织学指数评估。对患者平均随访5.7±3.3年。使用逻辑回归和广义估计方程来确定与发炎的结肠粘膜中瘤形成的检测相关的临床,内镜和组织学因素。

结果
在接受1277例结肠镜检查的398例患者中,确定了45例CRN患者。与CRN相关的因素是原发性硬化性胆管炎(优势比[OR]为2.65; 95%CI为1.06-6.61;P=.04),年龄(每1年增加OR,1.04;95%CI为1.01-1.07;P=.003),以及随访评估中的平均南希组织学指数(每增加1个单位,OR,1.69;95%CI,1.29–2.21;P<.001)。调整确定的因素后,将慢性疾病溃疡与CRN的风险增加无关(OR,1.24;95%CI,0.53-2.91;P=0.62 )。

结论
本项研究表明IBD患者南希组织学评分与CRN的发展相关联。

原始出处:

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    2020-07-29 许安
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    2019-12-29 zll0628
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