Diabetes：过量饱和脂肪酸致肝脂肪蓄积

2014-02-25 高晓方译医学论坛网

瑞典一项研究表明，在健康人群中，过量摄入饱和脂肪酸(SFA)可导致肝脏和内脏脂肪蓄积，过量摄入多不饱和脂肪酸(PUFA)则可促进无脂肪组织增加。论文于2月18日在线发表于《糖尿病》(Diabetes)杂志。【原文下载】此项双盲、平行组、随机试验共纳入39例体重正常的青年受试者，并且受试者在7周期间过量摄入SFA(棕榈油)或PUFA(葵花籽油)高含量松饼。利用MRI评估肝脏脂肪、内脏脂肪(VAT

瑞典一项研究表明，在健康人群中，过量摄入饱和脂肪酸(SFA)可导致肝脏和内脏脂肪蓄积，过量摄入多不饱和脂肪酸(PUFA)则可促进无脂肪组织增加。论文于2月18日在线发表于《糖尿病》(Diabetes)杂志。【原文下载】

此项双盲、平行组、随机试验共纳入39例体重正常的青年受试者，并且受试者在7周期间过量摄入SFA(棕榈油)或PUFA(葵花籽油)高含量松饼。利用MRI评估肝脏脂肪、内脏脂肪(VAT)、腹部皮下脂肪(SAT)、总脂肪组织(TAT)、胰腺脂肪和无脂肪组织。在SAT中实施转录组学评估。

结果显示，两组受试者的体重增加程度相似。与PUFA相比，SFA使肝脏脂肪显著增多，并导致VAT增加两倍。与SFA相比，PUFA使无脂肪组织增加近三倍。肝脏脂肪增多与血浆SFA变化直接相关，并与PUFA呈负相关。涉及能量耗散、胰岛素抵抗、身体成分和脂肪细胞分化的调控基因在两组受试者中出现差异表达。

原始出处：

Rosqvist F1, Iggman D, Kullberg J, Jonathan Cedernaes J, Johansson HE, Larsson A, Johansson L, Ahlström H, Arner P, Dahlman I, Risérus U.Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans.Diabetes. 2014 Feb 18. 【原文下载】

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好好学习

133 0
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2016-03-18 忠诚向上

好好学习

116 0
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2016-03-18 忠诚向上

好好学习

113 0
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2016-03-18 忠诚向上

好好学习

113 0
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2016-03-18 忠诚向上

好好学习

94 0
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2016-03-18 忠诚向上

好好学习

88 0
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2016-03-18 忠诚向上

好好学习

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