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Nanomaterials：GO-Ag纳米材料或可用于乳腺癌的靶向治疗

2017-12-04 MedSci MedSci原创

GO-Ag乳腺癌
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石墨烯材料由于其多功能的生物学应用和非凡的性能而引起了研究人员的广泛关注。氧化石墨烯（GO）是石墨烯的一种氧化形式，其表面含有氧官能团。GO可与银纳米粒子结合（Ag NPs）产生了氧化石墨烯-银纳米粒子（GO-Ag）纳米复合材料。在该实验研究中，研究人员在体外人乳腺癌模型中评估了氧化石墨烯-银（GO-Ag）纳米复合材料的毒性以优化光动力疗法的参数。采用水热法制备GO-Ag，采用X射线衍射、场发射扫

石墨烯材料由于其多功能的生物学应用和非凡的性能而引起了研究人员的广泛关注。氧化石墨烯（GO）是石墨烯的一种氧化形式，其表面含有氧官能团。GO可与银纳米粒子结合（Ag NPs）产生了氧化石墨烯-银纳米粒子（GO-Ag）纳米复合材料。

在该实验研究中，研究人员在体外人乳腺癌模型中评估了氧化石墨烯-银（GO-Ag）纳米复合材料的毒性以优化光动力疗法的参数。采用水热法制备GO-Ag，采用X射线衍射、场发射扫描电镜（FE-SEM）、透射电子显微镜（TEM）、能量色散X射线分析（EDAX）、原子力显微镜力显微镜和紫外-可见光谱表征GO-Ag。实验是在激光照射下及黑暗中进行，以检查纳米复合材料的光毒性和细胞毒性。

结果显示，MTT测定和细胞内活性氧产生表明GO-Ag存在细胞毒性。光毒性作用研究显示，细胞活力呈剂量依赖性降低，且细胞死亡通过凋亡引起。激光照射下的样品中¹O2的水平明显升高。对实验结果进行统计分析以确认结果的价值和准确性，p值<0.05为有统计学意义。

总之，这些结果表明，GO-Ag纳米复合材料可以作为靶向乳腺癌治疗的潜在应用材料。

原始出处：

Shaheen F, Hammad Aziz M, et al., An In Vitro Study of the Photodynamic Effectiveness of GO-Ag Nanocomposites against Human Breast Cancer Cells. Nanomaterials (Basel). 2017 Nov 21;7(11). pii: E401. doi: 10.3390/nano7110401.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2036543, encodeId=cd9b2036543ed, content=<a href='/topic/show?id=a7ab815e10' target=_blank style='color:#2F92EE;'>#GO-Ag#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8157, encryptionId=a7ab815e10, topicName=GO-Ag)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49ef408, createdName=hunizi005, createdTime=Sun Jul 01 21:41:00 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479478, encodeId=2af214e94785a, content=<a href='/topic/show?id=1e30e739295' target=_blank style='color:#2F92EE;'>#纳米材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77392, encryptionId=1e30e739295, topicName=纳米材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cde87531954, createdName=12498710m13暂无昵称, createdTime=Wed Dec 06 12:41:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266921, encodeId=01792669211b, content=谢谢分享.阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Dec 05 08:18:21 CST 2017, time=2017-12-05, status=1, ipAttribution=)]
    2018-07-01 hunizi005

    #GO-Ag#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2036543, encodeId=cd9b2036543ed, content=<a href='/topic/show?id=a7ab815e10' target=_blank style='color:#2F92EE;'>#GO-Ag#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8157, encryptionId=a7ab815e10, topicName=GO-Ag)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49ef408, createdName=hunizi005, createdTime=Sun Jul 01 21:41:00 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479478, encodeId=2af214e94785a, content=<a href='/topic/show?id=1e30e739295' target=_blank style='color:#2F92EE;'>#纳米材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77392, encryptionId=1e30e739295, topicName=纳米材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cde87531954, createdName=12498710m13暂无昵称, createdTime=Wed Dec 06 12:41:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266921, encodeId=01792669211b, content=谢谢分享.阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Dec 05 08:18:21 CST 2017, time=2017-12-05, status=1, ipAttribution=)]
    2017-12-06 12498710m13暂无昵称

    #纳米材料#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2036543, encodeId=cd9b2036543ed, content=<a href='/topic/show?id=a7ab815e10' target=_blank style='color:#2F92EE;'>#GO-Ag#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8157, encryptionId=a7ab815e10, topicName=GO-Ag)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49ef408, createdName=hunizi005, createdTime=Sun Jul 01 21:41:00 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479478, encodeId=2af214e94785a, content=<a href='/topic/show?id=1e30e739295' target=_blank style='color:#2F92EE;'>#纳米材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77392, encryptionId=1e30e739295, topicName=纳米材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cde87531954, createdName=12498710m13暂无昵称, createdTime=Wed Dec 06 12:41:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266921, encodeId=01792669211b, content=谢谢分享.阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Dec 05 08:18:21 CST 2017, time=2017-12-05, status=1, ipAttribution=)]
    2017-12-05 刘煜

    谢谢分享.阅读

    0

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