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Neurology:酒精摄入与脑出血风险分析!

2017-04-27 xing.T MedSci原创

该研究的结果表明罕见的和适度的饮酒对ICH风险具有潜在的保护效应。重度饮酒与ICH风险增加相关。民族/种族是酒精相关的ICH风险的一个重要因素;黑人和西班牙裔人重度饮酒可以显著增加非脑叶ICH风险。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在分析颅内出血(ICH)民族/种族变异研究(ERICH研究)中酒精摄入量和ICH之间的剂量-风险关系。

ERICH研究是一项多中心、前瞻性、病例对照研究,其招募了1000名非西班牙裔白人ICH患者、1000名非西班牙裔黑人ICH患者和1000名西班牙裔ICH患者。所有患者按1:1比例匹配年龄、性别、民族/种族、地理区域的非ICH对照者。全面访谈中包括酒精摄入量。根据酒精摄入量参与者被分类为:不饮酒、罕见(每月饮酒<1杯)、轻度(每月饮酒≥1杯,但每天饮酒≤2杯)、中度(每天饮酒≥2杯,但每天饮酒<5杯)和重度(每天饮酒≥5杯)。研究人员采用不饮酒组作为参考组计算ICH风险。

多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势:罕见(比值比为0.57,P<0.0001),轻度(比值比为0.65,P<0.0001),中间(比值比为0.82,P=0.2666)和重度酒精摄入量(风险比为1.77,P=0.0003)。亚组分析显示罕见的和轻度饮酒可以降低脑叶与非脑叶ICH风险,重度饮酒与非脑叶ICH风险增加显著相关(比值比为2.04,P=0.0003)。重度饮酒与黑人(风险比为2.34,P=0.0140)和西班牙裔(比值比为12.32,P<0.0001)参与者的非脑叶ICH风险显著增加相关。而在白人参与者中没有发现类似的相关性。

该研究的结果表明罕见的和适度的饮酒对ICH风险具有潜在的保护效应。重度饮酒与ICH风险增加相关。民族/种族是酒精相关的ICH风险的一个重要因素;黑人和西班牙裔人重度饮酒可以显著增加非脑叶ICH风险。

原始出处:

Ching-Jen Chen, et al. Alcohol use and risk of intracerebral hemorrhage. Neurology. 2017. http://dx.doi.org/10.1212/WNL.0000000000003952

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encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-08-22 yinhl1978
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    2017-09-22 一个字-牛

    学习了谢谢分享

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Apr 27 23:38:05 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191176, encodeId=b6471911e6be, content=国人更需要酱紫的研究啊,因为国人的脑出血发生率更高,而具体机制尚不清楚。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu Apr 27 17:44:51 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191113, encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-05-02 laoli

    看来还是少喝好!

    0

  5. 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    2017-04-28 虈亣靌

    感谢梅斯医学一直提供这么专业这么有价值的内容

    0

  6. 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encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-04-28 三生有幸9135

    学习一下谢谢分享

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Apr 27 23:38:05 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191176, encodeId=b6471911e6be, content=国人更需要酱紫的研究啊,因为国人的脑出血发生率更高,而具体机制尚不清楚。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu Apr 27 17:44:51 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191113, encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-04-28 dachengl

    小喝怡情,大喝伤身,强喝灰飞烟灭

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Apr 27 23:38:05 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191176, encodeId=b6471911e6be, content=国人更需要酱紫的研究啊,因为国人的脑出血发生率更高,而具体机制尚不清楚。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu Apr 27 17:44:51 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191113, encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-04-27 tanxingdoctor

    学习啦,谢谢分享

    0

  9. 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encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-04-27 baihao215

    国人更需要酱紫的研究啊,因为国人的脑出血发生率更高,而具体机制尚不清楚。

    0

  10. 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encodeId=40fc19111392, content=多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Thu Apr 27 15:18:24 CST 2017, time=2017-04-27, status=1, ipAttribution=)]
    2017-04-27 knowheart

    多变量分析结果证实了ICH风险随酒精摄入量呈顺序趋势

    0

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