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Neurology:HIV感染者 早诊早治有助减少神经认知损害

2013-02-05 李妍 编译 中国医学论坛报

  美国一项研究显示,人类免疫缺陷病毒(HIV)感染者,在感染早期获得诊治,神经认知功能损害(NCI)发生率与未感染者相当。论文发表于《神经病学》[Neurology 2013,80(4):371]杂志。   研究纳入200例HIV感染者(HIV+,中位年龄36岁,中位感染时间为5年),以及50名匹配 对照(HIV-)。HIV+被分为感染早期(感染<6年,无艾滋病相关表现,最

  美国一项研究显示,人类免疫缺陷病毒(HIV)感染者,在感染早期获得诊治,神经认知功能损害(NCI)发生率与未感染者相当。论文发表于《神经病学》[Neurology 2013,80(4):371]杂志。

  研究纳入200例HIV感染者(HIV+,中位年龄36岁,中位感染时间为5年),以及50名匹配 对照(HIV-)。HIV+被分为感染早期(感染<6年,无艾滋病相关表现,最低CD4细胞计数>200/mm3,n=100)和晚期(n=100)两组,均获得早期诊断和治疗。当前64%在接受高效抗逆转录病毒治疗(在诊断后1.3年、中位CD4计数333/mm3时开始)。

  结果为,共38例HIV+者(19%)发生NCI ,发生率在早期和晚期HIV感染者中相当(18%对20%,P=0.72),且与HIV-者NCI发生率相当。



    

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    2013-11-07 yinhl1978
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