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Diabetes Care:超敏肌钙蛋白T(hs-cTnT)还能预测糖尿病!

2016-11-17 MedSci MedSci原创

许多个体有亚临床心肌损害的前期证据,心血管病(CVD)的风险增加。如果亚临床心肌损伤与糖尿病独立相关,这将有助于我们对糖尿病和心血管疾病之间的关联的理解。进行这项研究,以确定超敏肌钙蛋白T(hs-cTnT)是否与糖尿病相关。 利用Kaplan Meier曲线和Cox模型,我们前瞻性的分析了8153名无糖尿病或心血管疾病参与者的数据。我们使用Harrell C统计,调查hs-cTnT是否与糖尿

许多个体有亚临床心肌损害的前期证据,心血管病(CVD)的风险增加。如果亚临床心肌损伤与糖尿病独立相关,这将有助于我们对糖尿病和心血管疾病之间的关联的理解。进行这项研究,以确定超敏肌钙蛋白T(hs-cTnT)是否与糖尿病相关。

利用Kaplan Meier曲线和Cox模型,我们前瞻性的分析了8153名无糖尿病或心血管疾病参与者的数据。我们使用Harrell C统计,调查hs-cTnT是否与糖尿病相关。

在平均13年的随访中,有1830例诊断为糖尿病。调整人口和传统危险因素后,基线hs-cTnT为9–13 ng/L或≥14 ng/L的参与者,与hs-cTnT ≤5 ng/L的参与者比较,患糖尿病的风险显著增加,HR值分别为1.14 (95% CI 0.99–1.33)和1.25 ( 95% CI 1.03–1.53)(P = 0.018)。包括调整基线空腹血糖的线性样条建模分析显示,hs-cTnT >8 ng/L与糖尿病风险的增加有关。此外,将hs-cTnT添加到充分调整的模型中,可显著改善糖尿病的预测,从0.7636到0.7644 (P = 0.023)。

基线hs-cTnT水平升高者发生糖尿病的风险增加,这表明hs-cTnT可能与糖尿病和心血管疾病之间的潜在的病理生理反应有关,而不能被其他传统危险因素所解释。

测量hs-cTnT可以识别糖尿病和心血管疾病风险增加人群,以实现早干预,降低发病率。

原始出处:

Seamus P. Whelton,et al.High-Sensitivity Cardiac Troponin T (hs-cTnT) as a Predictor of Incident Diabetes in the Atherosclerosis Risk in Communities Study.Diabetes Care 2016 Nov

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createdBy=565a98798, createdName=susice, createdTime=Fri Nov 18 12:59:12 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156550, encodeId=e5fd156550aa, content=专业学习糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825E270980429526.jpg, createdBy=f49f1974260, createdName=我是林下之夕, createdTime=Fri Nov 18 08:25:39 CST 2016, time=2016-11-18, status=1, ipAttribution=)]
    2016-11-24 李东泽

    很好,不错,以后会多学习

    0

  6. 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createdBy=565a98798, createdName=susice, createdTime=Fri Nov 18 12:59:12 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156550, encodeId=e5fd156550aa, content=专业学习糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825E270980429526.jpg, createdBy=f49f1974260, createdName=我是林下之夕, createdTime=Fri Nov 18 08:25:39 CST 2016, time=2016-11-18, status=1, ipAttribution=)]
    2016-11-19 zhouqu_8
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createdBy=565a98798, createdName=susice, createdTime=Fri Nov 18 12:59:12 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156550, encodeId=e5fd156550aa, content=专业学习糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825E270980429526.jpg, createdBy=f49f1974260, createdName=我是林下之夕, createdTime=Fri Nov 18 08:25:39 CST 2016, time=2016-11-18, status=1, ipAttribution=)]
  8. 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  9. 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createdBy=565a98798, createdName=susice, createdTime=Fri Nov 18 12:59:12 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156550, encodeId=e5fd156550aa, content=专业学习糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825E270980429526.jpg, createdBy=f49f1974260, createdName=我是林下之夕, createdTime=Fri Nov 18 08:25:39 CST 2016, time=2016-11-18, status=1, ipAttribution=)]
    2016-11-18 susice

    收藏

    0

  10. 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createdBy=565a98798, createdName=susice, createdTime=Fri Nov 18 12:59:12 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156550, encodeId=e5fd156550aa, content=专业学习糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825E270980429526.jpg, createdBy=f49f1974260, createdName=我是林下之夕, createdTime=Fri Nov 18 08:25:39 CST 2016, time=2016-11-18, status=1, ipAttribution=)]
    2016-11-18 我是林下之夕

    专业学习糖尿病

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