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Janssen购买了Legend的CART疗法

2017-12-24 MedSci MedSci原创

JanssenLegendCART疗法
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Janssen已经与Legend Biotech USA和Legend Biotech Ireland签署了一项全球协作和许可协议，开发，制造和销售实验性CART细胞疗法LCAR-B38M。目前，中国的监管机构正在对LCAR-B38M进行研究，该研究专门针对B细胞成熟抗原（BCMA），这是一种在骨髓瘤细胞中高表达的蛋白质，在美国临床研究的计划阶段正在进行多发性骨髓瘤的研究。根据协议条款，作为3.5


Janssen已经与Legend Biotech USA和Legend Biotech Ireland签署了一项全球协作和许可协议，开发，制造和销售实验性CART细胞疗法LCAR-B38M。

目前，中国的监管机构正在对LCAR-B38M进行研究，该研究专门针对B细胞成熟抗原（BCMA），这是一种在骨髓瘤细胞中高表达的蛋白质，在美国临床研究的计划阶段正在进行多发性骨髓瘤的研究。

根据协议条款，作为3.5亿美元的前期费用，Janssen获得了全球许可，联合开发和交付LCAR-B38M多发性骨髓瘤与Legend专家团队。

Legend控股还将根据某些发展、监管和销售里程碑的成就，获得额外的报酬。

除了在大中华地区，Janssen和Legend的成本分成/利润分配比例达到30/70％之外，这两家公司已经达到了50/50的成本分摊/利润分配。

"尽管取得了重大进展，多发性骨髓瘤仍然是绝大多数患者不可治愈的疾病，因此需要额外的高度活跃的选择。"LCAR-B38M提供了一种创新方法，可以改变骨髓瘤的治疗方法，" Janssen研发部肿瘤学全球治疗领域负责人Peter Lebowitz说。

Legend公司是中国投资控股公司Genscript Biotech Corporation的子公司。


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    2017-12-26 zhaojie88

    #ART#

    0

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    2017-12-26 ms2999106592497887

    #cART#

    0

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    2017-12-26 zhang92564

    #Janssen#

    0

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    2017-12-26 gaoxiaoe

    #CART疗法#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1356605, encodeId=2536135660574, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477254, encodeId=21c914e725437, content=<a href='/topic/show?id=429a41149d' target=_blank style='color:#2F92EE;'>#cART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4114, encryptionId=429a41149d, topicName=cART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46987366013, createdName=ms2999106592497887, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527084, encodeId=0e87152e0841a, content=<a href='/topic/show?id=ad4410248b5' target=_blank style='color:#2F92EE;'>#Janssen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10248, encryptionId=ad4410248b5, topicName=Janssen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ca11798386, createdName=zhang92564, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621461, encodeId=2f6c1621461a2, content=<a href='/topic/show?id=a5bc411e36' target=_blank style='color:#2F92EE;'>#CART疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4117, encryptionId=a5bc411e36, topicName=CART疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc3f20265747, createdName=gaoxiaoe, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272153, encodeId=c4612e2153fe, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Dec 24 15:43:22 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272148, encodeId=470a2e214882, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 24 13:51:09 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272122, encodeId=1a082e21221e, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sun Dec 24 13:16:39 CST 2017, time=2017-12-24, status=1, ipAttribution=)]
    2017-12-24 changjiu

    学习一下谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1356605, encodeId=2536135660574, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477254, encodeId=21c914e725437, content=<a href='/topic/show?id=429a41149d' target=_blank style='color:#2F92EE;'>#cART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4114, encryptionId=429a41149d, topicName=cART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46987366013, createdName=ms2999106592497887, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527084, encodeId=0e87152e0841a, content=<a href='/topic/show?id=ad4410248b5' target=_blank style='color:#2F92EE;'>#Janssen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10248, encryptionId=ad4410248b5, topicName=Janssen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ca11798386, createdName=zhang92564, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621461, encodeId=2f6c1621461a2, content=<a href='/topic/show?id=a5bc411e36' target=_blank style='color:#2F92EE;'>#CART疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4117, encryptionId=a5bc411e36, topicName=CART疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc3f20265747, createdName=gaoxiaoe, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272153, encodeId=c4612e2153fe, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Dec 24 15:43:22 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272148, encodeId=470a2e214882, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 24 13:51:09 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272122, encodeId=1a082e21221e, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sun Dec 24 13:16:39 CST 2017, time=2017-12-24, status=1, ipAttribution=)]
    2017-12-24 131****1460

    学习了受益匪浅

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1356605, encodeId=2536135660574, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477254, encodeId=21c914e725437, content=<a href='/topic/show?id=429a41149d' target=_blank style='color:#2F92EE;'>#cART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4114, encryptionId=429a41149d, topicName=cART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46987366013, createdName=ms2999106592497887, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527084, encodeId=0e87152e0841a, content=<a href='/topic/show?id=ad4410248b5' target=_blank style='color:#2F92EE;'>#Janssen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10248, encryptionId=ad4410248b5, topicName=Janssen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ca11798386, createdName=zhang92564, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621461, encodeId=2f6c1621461a2, content=<a href='/topic/show?id=a5bc411e36' target=_blank style='color:#2F92EE;'>#CART疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4117, encryptionId=a5bc411e36, topicName=CART疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc3f20265747, createdName=gaoxiaoe, createdTime=Tue Dec 26 01:51:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272153, encodeId=c4612e2153fe, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Dec 24 15:43:22 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272148, encodeId=470a2e214882, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 24 13:51:09 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272122, encodeId=1a082e21221e, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sun Dec 24 13:16:39 CST 2017, time=2017-12-24, status=1, ipAttribution=)]
    2017-12-24 hhh678

    henhao

    0

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